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Gene Review

ric-3  -  Protein RIC-3

Caenorhabditis elegans

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High impact information on ric-3

  • The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors [1].
  • Moreover, co-expression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors [1].
  • Quantification of the fluorescence is possible, as verified by demonstrating that mutations in ric-3 and unc-38, which cause behavioural resistance to cholinergic agonists, strongly reduce or even abolish nAChR cell surface expression [2].


  1. The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors. Halevi, S., McKay, J., Palfreyman, M., Yassin, L., Eshel, M., Jorgensen, E., Treinin, M. EMBO J. (2002) [Pubmed]
  2. Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans. Gottschalk, A., Schafer, W.R. J. Neurosci. Methods (2006) [Pubmed]
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