The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

unc-38  -  Protein UNC-38

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of unc-38


High impact information on unc-38

  • This response was eliminated in mutants lacking either the unc-38 or unc-29 genes, which encode alpha and non-alpha acetylcholine receptor subunits, respectively [2].
  • We show that three of the eleven genes of the nematode Caenorhabditis elegans that mediate resistance to the nematocide levamisole and to other cholinergic agonists encode nicotinic acetylcholine receptor (nAChR) subunits. unc-38 encodes an alpha subunit while lev-1 and unc-29 encode non-alpha subunits [3].
  • Expression in Xenopus oocytes of combinations of these subunits that include the unc-38 alpha subunit results in levamisole-induced currents that are suppressed by the nAChR antagonists mecamylamine, neosurugatoxin, and d-tubocurarine but not alpha-bungarotoxin [3].
  • A T. colubriformis genomic library in lambda EMBL3 was screened for sequences homologous to the Caenorhabditis elegans unc-38 nicotinic acetylcholine receptor (nAChR) alpha-subunit gene [4].
  • Hcal is related to unc-38, a nicotinic acetylcholine receptor subunit gene associated with levamisole resistance in Caenorhabditis elegans [5].

Biological context of unc-38


Other interactions of unc-38

  • Quantification of the fluorescence is possible, as verified by demonstrating that mutations in ric-3 and unc-38, which cause behavioural resistance to cholinergic agonists, strongly reduce or even abolish nAChR cell surface expression [6].
  • Together with five other alpha subunit genes described elsewhere by ourselves (unc-38) and other workers (deg-3, acr-4, Ce21 and acr-6), this is now the largest known family of nAChR alpha subunit genes in a single species [7].


  1. Genes affecting the activity of nicotinic receptors involved in Caenorhabditis elegans egg-laying behavior. Kim, J., Poole, D.S., Waggoner, L.E., Kempf, A., Ramirez, D.S., Treschow, P.A., Schafer, W.R. Genetics (2001) [Pubmed]
  2. One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Richmond, J.E., Jorgensen, E.M. Nat. Neurosci. (1999) [Pubmed]
  3. Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. Fleming, J.T., Squire, M.D., Barnes, T.M., Tornoe, C., Matsuda, K., Ahnn, J., Fire, A., Sulston, J.E., Barnard, E.A., Sattelle, D.B., Lewis, J.A. J. Neurosci. (1997) [Pubmed]
  4. Cloning and sequence analysis of the candidate nicotinic acetylcholine receptor alpha subunit gene tar-1 from Trichostrongylus colubriformis. Wiley, L.J., Weiss, A.S., Sangster, N.C., Li, Q. Gene (1996) [Pubmed]
  5. Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance. Hoekstra, R., Visser, A., Wiley, L.J., Weiss, A.S., Sangster, N.C., Roos, M.H. Mol. Biochem. Parasitol. (1997) [Pubmed]
  6. Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans. Gottschalk, A., Schafer, W.R. J. Neurosci. Methods (2006) [Pubmed]
  7. An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans. Mongan, N.P., Baylis, H.A., Adcock, C., Smith, G.R., Sansom, M.S., Sattelle, D.B. Recept. Channels (1998) [Pubmed]
WikiGenes - Universities