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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

egl-20  -  Protein EGL-20

Caenorhabditis elegans

 
 
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High impact information on egl-20

  • Interfering with pop-1 zygotic function caused defects in the migration of the QL descendants that mimicked the defects in egl-20/Wnt mutants and blocked the expression of mab-5 [1].
  • Here we report that egl-20, a C. elegans gene required to activate expression of the Hox gene mab-5 in the migratory neuroblast QL, encodes a member of the Wnt family of secreted glycoproteins [2].
  • The strongest defects we observed were in the lin-44; cwn-1; egl-20 triple mutant [3].
 

Biological context of egl-20

  • The reversal in the migration of the left Q neuroblast and its descendants resulted from a failure to express mab-5, an egl-20 mutant phenotype [4].

References

  1. C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity. Herman, M. Development (2001) [Pubmed]
  2. A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Maloof, J.N., Whangbo, J., Harris, J.M., Jongeward, G.D., Kenyon, C. Development (1999) [Pubmed]
  3. Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development. Gleason, J.E., Szyleyko, E.A., Eisenmann, D.M. Dev. Biol. (2006) [Pubmed]
  4. The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. Forrester, W.C., Kim, C., Garriga, G. Genetics (2004) [Pubmed]
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