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Gene Review

egl-20  -  Protein EGL-20

Caenorhabditis elegans

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High impact information on egl-20

  • Interfering with pop-1 zygotic function caused defects in the migration of the QL descendants that mimicked the defects in egl-20/Wnt mutants and blocked the expression of mab-5 [1].
  • Here we report that egl-20, a C. elegans gene required to activate expression of the Hox gene mab-5 in the migratory neuroblast QL, encodes a member of the Wnt family of secreted glycoproteins [2].
  • The strongest defects we observed were in the lin-44; cwn-1; egl-20 triple mutant [3].

Biological context of egl-20

  • The reversal in the migration of the left Q neuroblast and its descendants resulted from a failure to express mab-5, an egl-20 mutant phenotype [4].


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