Gene Review:
cwn-1 - Protein CWN-1
Caenorhabditis elegans
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High impact information on cwn-1
- Ce-wnt-1 is localized to the left arm of chromosome II and Ce-wnt-2 maps to a cluster of genes on chromosome IV [1].
- In contrast to mammalian and insect wnt genes with four or five exons and conserved intron-exon boundaries, Ce-wnt-1 has nine coding exons; only one of the eight identified introns interrupts the coding sequence at a position homologous to an intron position in other wnt genes [1].
- The major transcript derived from Ce-wnt-1 is 1.4 kb in length, and the 22 nucleotides at its 5' end are added by a trans-splicing mechanism [1].
References
- Two wnt genes in Caenorhabditis elegans. Shackleford, G.M., Shivakumar, S., Shiue, L., Mason, J., Kenyon, C., Varmus, H.E. Oncogene (1993) [Pubmed]
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