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Gene Review

Myh2  -  myosin, heavy polypeptide 2, skeletal...

Mus musculus

Synonyms: MHC2A, MyHC-IIa, Myh2a, Myhs-f, Myhs-f1, ...
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High impact information on Myh2

  • Despite this universal compensation of MyHC-IIa expression, IId null mice have severe phenotypes [1].
  • Reinnervation following transient neonatal denervation of both the +/+ and the dy/dy EDL muscles results in a similar decrease (approximately 62%) in the number of myofibers containing MHC2B and an increase in myofibers containing the other fast MHC isoforms (MHC2A and MHC2X) [2].

Anatomical context of Myh2


  1. Myosin heavy chains IIa and IId are functionally distinct in the mouse. Sartorius, C.A., Lu, B.D., Acakpo-Satchivi, L., Jacobsen, R.P., Byrnes, W.C., Leinwand, L.A. J. Cell Biol. (1998) [Pubmed]
  2. Modification of the dystrophic phenotype after transient neonatal denervation: role of MHC isoforms. Ontell, M.P., Moschella, M.C., Schiaffino, S., Butler-Browne, G., Whalen, R., Ontell, M. J. Neurobiol. (1992) [Pubmed]
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