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Gene Review

Myh4  -  myosin, heavy polypeptide 4, skeletal muscle

Mus musculus

Synonyms: AI506973, MHC2B, MM, MYH-2B, Minimsc, ...
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High impact information on Myh4

  • MyHC-IIb content was unaffected in all muscles except the masseter, where its expression was extinguished in the IId null mice [1].
  • Reinnervation following transient neonatal denervation of both the +/+ and the dy/dy EDL muscles results in a similar decrease (approximately 62%) in the number of myofibers containing MHC2B and an increase in myofibers containing the other fast MHC isoforms (MHC2A and MHC2X) [2].

Anatomical context of Myh4

  • In the present study, the expression of seven sarcomeric MyHCs was analyzed in the hindlimb muscles of wild-type mice and in mice null for the MyHC IIb or IId/x genes at several time points from 1 day of postnatal life (dpn) to 20 dpn [3].


  1. Myosin heavy chains IIa and IId are functionally distinct in the mouse. Sartorius, C.A., Lu, B.D., Acakpo-Satchivi, L., Jacobsen, R.P., Byrnes, W.C., Leinwand, L.A. J. Cell Biol. (1998) [Pubmed]
  2. Modification of the dystrophic phenotype after transient neonatal denervation: role of MHC isoforms. Ontell, M.P., Moschella, M.C., Schiaffino, S., Butler-Browne, G., Whalen, R., Ontell, M. J. Neurobiol. (1992) [Pubmed]
  3. Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains. Allen, D.L., Leinwand, L.A. Dev. Biol. (2001) [Pubmed]
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