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Gene Review:

recA - recombinase A

Deinococcus radiodurans R1

Liu, Y. et al., Hua, Y. et al., Earl, A.M. et al., Sheng, D. et al.

Hua, Narumi, Gao, Tian, Satoh, Kitayama, Shen,

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Disease relevance of recA

The IrrE protein of Deinococcus radiodurans R1 is a novel regulator of recA expression [1].

High impact information on recA

DEIRA recA, which is central to genomic restoration after irradiation, is substantially up-regulated on DNA damage (early phase) and down-regulated before the onset of exponential growth (late phase) [2].
In response to radiation stress, PprI can significantly and specifically induce the gene expression of recA and pprA and enhance the enzyme activities of catalases [3].
LexA analog (dra0074) is a regulatory protein that is irrelevant to recA induction [4].

References

The IrrE protein of Deinococcus radiodurans R1 is a novel regulator of recA expression. Earl, A.M., Mohundro, M.M., Mian, I.S., Battista, J.R. J. Bacteriol. (2002) [Pubmed]
Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation. Liu, Y., Zhou, J., Omelchenko, M.V., Beliaev, A.S., Venkateswaran, A., Stair, J., Wu, L., Thompson, D.K., Xu, D., Rogozin, I.B., Gaidamakova, E.K., Zhai, M., Makarova, K.S., Koonin, E.V., Daly, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans. Hua, Y., Narumi, I., Gao, G., Tian, B., Satoh, K., Kitayama, S., Shen, B. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
LexA analog (dra0074) is a regulatory protein that is irrelevant to recA induction. Sheng, D., Zheng, Z., Tian, B., Shen, B., Hua, Y. J. Biochem. (2004) [Pubmed]

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