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Gene Review

Nedd8  -  neural precursor cell expressed,...

Mus musculus

Synonyms: NEDD-8, NEDD8, Nedd-8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8, ...
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Disease relevance of Nedd8

  • To target and identify UBL-modifying enzymes, we produced Nedd8, ISG15, and SUMO-1 in Escherichia coli and equipped them with a C-terminal electrophilic trap (vinyl sulfone [VS]) via an intein-based method [1].


  1. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Hemelaar, J., Borodovsky, A., Kessler, B.M., Reverter, D., Cook, J., Kolli, N., Gan-Erdene, T., Wilkinson, K.D., Gill, G., Lima, C.D., Ploegh, H.L., Ovaa, H. Mol. Cell. Biol. (2004) [Pubmed]
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