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Gene Review

RUB1  -  NEDD8 family protein RUB1

Saccharomyces cerevisiae S288c

Synonyms: NEDD8-like protein RUB1, Related to ubiquitin protein 1, Ubiquitin-like protein RUB1, YD9302.15C, YDR139C
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High impact information on RUB1

  • Our findings identify Rbx1 as a common component of enzyme systems responsible for ubiquitin and Rub1 modification of target proteins [1].
  • Two genes have been identified that are required for Rub1p conjugation to Cdc53p [2].
  • By analogy with Aos1p, we infer that Enr2p functions in a bipartite Rub1p-activating enzyme [2].
  • Conjugation of RUB1 is not essential for normal cell growth and appears to be selective for a small set of substrates [3].
  • NEDD8/Rub1 is the most homologous protein to ubiquitin among the ubiquitin-like proteins, and it is covalently linked to target proteins via the C-terminal glycine residue in a manner analogous to ubiquitylation [4].

Associations of RUB1 with chemical compounds

  • An rtt101 Delta strain was hypersensitive to thiabendazole, isopropyl ( N -3-chlorophenyl) carbamate and methyl methanesulphonate, but rub1 Delta strains were not [5].
  • These results suggest that this lysine residue is the site of Rub1p-dependent and -independent modifications in Rtt101p and of Rub1p-dependent modification in Cul3p [5].
  • Before protein conjugation, the carboxyl-terminal asparagine residue of Rub1p is removed [6].

Other interactions of RUB1


  1. The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Kamura, T., Conrad, M.N., Yan, Q., Conaway, R.C., Conaway, J.W. Genes Dev. (1999) [Pubmed]
  2. Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Lammer, D., Mathias, N., Laplaza, J.M., Jiang, W., Liu, Y., Callis, J., Goebl, M., Estelle, M. Genes Dev. (1998) [Pubmed]
  3. A novel protein modification pathway related to the ubiquitin system. Liakopoulos, D., Doenges, G., Matuschewski, K., Jentsch, S. EMBO J. (1998) [Pubmed]
  4. But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast. Yashiroda, H., Tanaka, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  5. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Laplaza, J.M., Bostick, M., Scholes, D.T., Curcio, M.J., Callis, J. Biochem. J. (2004) [Pubmed]
  6. Rub1p processing by Yuh1p is required for wild-type levels of Rub1p conjugation to Cdc53p. Linghu, B., Callis, J., Goebl, M.G. Eukaryotic Cell (2002) [Pubmed]
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