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Gene Review

apl-1  -  Protein APL-1

Caenorhabditis elegans



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High impact information on apl-1

  • Hypodermal overexpression of APL-1 prolongs lifespan via heterochronic gene LIN-14   
  • The extracellular domain of APL-1 modulates multiple metabolic pathways, such as developmental progression, body size, and egg-laying rate, via the FOXO transcription factor DAF-16 and the nuclear hormone receptor DAF-12 [1].
  • apl-1(yn5) mutants show a temperature-sensitive lethality and developmental arrest. This apl-1(yn5) lethality phenotype is enhanced by mutation in MOA-2/B0495.6, a protein involved in receptor-mediated endocytosis, and is suppressed by a mutation in MOA-1/R155.2, a receptor-protein tyrosine phosphatase [1]
  • Neuronal overexpression of APL-1 disrupts multiple forms of learning (e.g. olfactory, gustatory, and touch plasticity) via the FOXO transcription factor DAF-16 and the nuclear hormone receptor DAF-12  [2].
  • The apl-1 transcripts undergo two forms of posttranscriptional modification: trans-splicing and alternative polyadenylylation [3].
  • feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping [4].


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