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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

apl-1  -  Protein APL-1

Caenorhabditis elegans

 
 

  

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High impact information on apl-1

  • Hypodermal overexpression of APL-1 prolongs lifespan via heterochronic gene LIN-14   
  • The extracellular domain of APL-1 modulates multiple metabolic pathways, such as developmental progression, body size, and egg-laying rate, via the FOXO transcription factor DAF-16 and the nuclear hormone receptor DAF-12 [1].
  • apl-1(yn5) mutants show a temperature-sensitive lethality and developmental arrest. This apl-1(yn5) lethality phenotype is enhanced by mutation in MOA-2/B0495.6, a protein involved in receptor-mediated endocytosis, and is suppressed by a mutation in MOA-1/R155.2, a receptor-protein tyrosine phosphatase [1]. 
  • Neuronal overexpression of APL-1 disrupts multiple forms of learning (e.g. olfactory, gustatory, and touch plasticity) via the FOXO transcription factor DAF-16 and the nuclear hormone receptor DAF-12  [2].
  • The apl-1 transcripts undergo two forms of posttranscriptional modification: trans-splicing and alternative polyadenylylation [3].
  • feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping [4].

References

  1. APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development. Ewald, C.Y., Raps, D.A., Li, C. Genetics. (2012) [Pubmed]
  2. Pan-neuronal expression of APL-1, an APP-related protein, disrupts olfactory, gustatory, and touch plasticity in Caenorhabditis elegans. Ewald, C.Y., Cheng, R., Tolen, L., Shah, V., Gillani, A., Nasrin, A., Li, C. J. Neurosci. (2012) [Pubmed]
  3. apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. Daigle, I., Li, C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping. Zambrano, N., Bimonte, M., Arbucci, S., Gianni, D., Russo, T., Bazzicalupo, P. J. Cell. Sci. (2002) [Pubmed]
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