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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

oga-1  -  Protein OGA-1

Caenorhabditis elegans

 
 
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High impact information on oga-1

  • Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer [1].
  • The knockout of O-GlcNAcase (oga-1) in C. elegans mimics many of the metabolic and signaling changes associated with human insulin resistance and provides a genetically amenable model of non-insulin-dependent diabetes [1].

References

  1. Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Forsythe, M.E., Love, D.C., Lazarus, B.D., Kim, E.J., Prinz, W.A., Ashwell, G., Krause, M.W., Hanover, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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