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Gene Review:

sma-9 - Protein SMA-9

Caenorhabditis elegans

Foehr, M.L. et al., Liang, J. et al., Savage-Dunn, C. et al.

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High impact information on sma-9

Analysis of sma-9 mutant phenotypes demonstrates that SMA-9 activity is temporally and spatially restricted relative to known DBL-1 pathway components [1].
Four of these 11 genes, sma-9, sma-14, sma-16, and sma-20 affect male tail morphogenesis as well as body size [2].

Analytical, diagnostic and therapeutic context of sma-9

Surprisingly, mutations in the core components of the Sma/Mab TGFbeta signaling pathway suppressed the M lineage defects of sma-9 mutants without suppressing their body size defects [3].

References

The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling. Liang, J., Lints, R., Foehr, M.L., Tokarz, R., Yu, L., Emmons, S.W., Liu, J., Savage-Dunn, C. Development (2003) [Pubmed]
Genetic screen for small body size mutants in C. elegans reveals many TGFbeta pathway components. Savage-Dunn, C., Maduzia, L.L., Zimmerman, C.M., Roberts, A.F., Cohen, S., Tokarz, R., Padgett, R.W. Genesis (2003) [Pubmed]
An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGFbeta signaling during mesodermal patterning. Foehr, M.L., Lindy, A.S., Fairbank, R.C., Amin, N.M., Xu, M., Yanowitz, J., Fire, A.Z., Liu, J. Development (2006) [Pubmed]

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