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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

slo-2  -  Protein SLO-2

Caenorhabditis elegans

 
 
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Disease relevance of slo-2

  • We demonstrate in C. elegans that slo-2 mutants are hypersensitive to hypoxia, suggesting a conserved role for the slo-2 gene subfamily [1].
 

High impact information on slo-2

  • One of the two genes, F08B12.3 (Ce-slo-2), shows a relatively low amino acid sequence similarity to other Slo sequences and lacks key functional motifs, which are important for calcium and voltage sensing [2].

References

  1. The sodium-activated potassium channel is encoded by a member of the Slo gene family. Yuan, A., Santi, C.M., Wei, A., Wang, Z.W., Pollak, K., Nonet, M., Kaczmarek, L., Crowder, C.M., Salkoff, L. Neuron (2003) [Pubmed]
  2. Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca(2+)-activated K(+) channels. Lim, H.H., Park, B.J., Choi, H.S., Park, C.S., Eom, S.H., Ahnn, J. Gene (1999) [Pubmed]
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