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Disease relevance of Anoxia


Psychiatry related information on Anoxia


High impact information on Anoxia

  • Tissue damage-associated deep hypoxia, hypoxia-inducible factors, and hypoxia-induced accumulation of adenosine may represent one of the most fundamental and immediate tissue-protecting mechanisms, with adenosine A2A receptors triggering "OFF" signals in activated immune cells [11].
  • In yeast and bacteria, regulatory operons coordinate expression of genes responsible for adaptive responses to hypoxia and hyperoxia [12].
  • HCP 1 mRNA was highly expressed in duodenum and regulated by hypoxia [13].
  • Microarray analysis revealed that Sre1 activates sterol biosynthetic enzymes as in mammals, and, surprisingly, Sre1 also stimulates transcription of genes required for adaptation to hypoxia [14].
  • Siah2 null mice subjected to hypoxia displayed an impaired hyperpneic respiratory response and reduced levels of hemoglobin [15].

Chemical compound and disease context of Anoxia


Biological context of Anoxia


Anatomical context of Anoxia


Gene context of Anoxia

  • Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of vascular endothelial growth factor (VEGF) and is critical for initiating early cellular responses to hypoxia [36].
  • Thus, the control of PHD1/3 by Siah1a/2 constitutes another level of complexity in the regulation of HIF1alpha during hypoxia [15].
  • VEGF induction by hypoxia in c-src(-) cells is impaired, although there is a compensatory activation of Fyn [19].
  • During terminal branching, FGF expression is regulated by hypoxia, ensuring that tracheal structure matches cellular oxygen need [37].
  • These results indicate that amplification of normal HIF-1-dependent responses to hypoxia via loss of p53 function contributes to the angiogenic switch during tumorigenesis [38].
  • This conclusion is supported by the finding that HIF-1alpha down-regulation by Cre-mediated excision drastically decreased RAGE induction by hypoxia or desferrioxamine [39].
  • Treatment of tumour cells with the MEK1/2 inhibitors PD98059 or U0216, or expression of a dominant-negative form of ERK1 blocked HIF-1 activation in hypoxia without affecting HIF-1alpha induction, localization or binding of HIF-1beta [40].
  • We determined that one relevant target of miR-210 in hypoxia was Ephrin-A3 since miR-210 was necessary and sufficient to down-modulate its expression [41].
  • Although only a small amount of (3)H-FDG was incorporated by resting macrophages, a dramatic increase in (3)H-FDG uptake in both fibroblasts and macrophages was observed when these cells were exposed to inflammatory cytokines, such as TNFalpha and IL-1, and hypoxia [42].

Analytical, diagnostic and therapeutic context of Anoxia


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  5. Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells. Tenan, M., Fulci, G., Albertoni, M., Diserens, A.C., Hamou, M.F., El Atifi-Borel, M., Feige, J.J., Pepper, M.S., Van Meir, E.G. J. Exp. Med. (2000) [Pubmed]
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  13. Identification of an intestinal heme transporter. Shayeghi, M., Latunde-Dada, G.O., Oakhill, J.S., Laftah, A.H., Takeuchi, K., Halliday, N., Khan, Y., Warley, A., McCann, F.E., Hider, R.C., Frazer, D.M., Anderson, G.J., Vulpe, C.D., Simpson, R.J., McKie, A.T. Cell (2005) [Pubmed]
  14. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Hughes, A.L., Todd, B.L., Espenshade, P.J. Cell (2005) [Pubmed]
  15. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Nakayama, K., Frew, I.J., Hagensen, M., Skals, M., Habelhah, H., Bhoumik, A., Kadoya, T., Erdjument-Bromage, H., Tempst, P., Frappell, P.B., Bowtell, D.D., Ronai, Z. Cell (2004) [Pubmed]
  16. The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection. Welliver, R.C., Wong, D.T., Sun, M., Middleton, E., Vaughan, R.S., Ogra, P.L. N. Engl. J. Med. (1981) [Pubmed]
  17. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Maltepe, E., Schmidt, J.V., Baunoch, D., Bradfield, C.A., Simon, M.C. Nature (1997) [Pubmed]
  18. Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Barbour, B., Szatkowski, M., Ingledew, N., Attwell, D. Nature (1989) [Pubmed]
  19. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Mukhopadhyay, D., Tsiokas, L., Zhou, X.M., Foster, D., Brugge, J.S., Sukhatme, V.P. Nature (1995) [Pubmed]
  20. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Cosby, K., Partovi, K.S., Crawford, J.H., Patel, R.P., Reiter, C.D., Martyr, S., Yang, B.K., Waclawiw, M.A., Zalos, G., Xu, X., Huang, K.T., Shields, H., Kim-Shapiro, D.B., Schechter, A.N., Cannon, R.O., Gladwin, M.T. Nat. Med. (2003) [Pubmed]
  21. Surviving anoxia: a tale of two white matter tracts. Baltan, S. Crit. Rev. Neurobiol (2006) [Pubmed]
  22. Hypoxia modulates cholinergic but not opioid activation of G proteins in rat hippocampus. Hambrecht, V.S., Vlisides, P.E., Row, B.W., Gozal, D., Baghdoyan, H.A., Lydic, R. Hippocampus (2007) [Pubmed]
  23. A1 adenosine receptors play an essential role in protecting the embryo against hypoxia. Wendler, C.C., Amatya, S., McClaskey, C., Ghatpande, S., Fredholm, B.B., Rivkees, S.A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  24. Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis. Feala, J.D., Coquin, L., McCulloch, A.D., Paternostro, G. Mol. Syst. Biol. (2007) [Pubmed]
  25. Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells. Torii, S., Kobayashi, K., Takahashi, M., Katahira, K., Goryo, K., Matsushita, N., Yasumoto, K., Fujii-Kuriyama, Y., Sogawa, K. J. Biol. Chem. (2009) [Pubmed]
  26. Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells. Tak, E., Lee, S., Lee, J., Rashid, M.A., Kim, Y.W., Park, J.H., Park, W.S., Shokat, K.M., Ha, J., Kim, S.S. J. Hepatol. (2011) [Pubmed]
  27. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila. Wingrove, J.A., O'Farrell, P.H. Cell (1999) [Pubmed]
  28. p63 is a p53 homologue required for limb and epidermal morphogenesis. Mills, A.A., Zheng, B., Wang, X.J., Vogel, H., Roop, D.R., Bradley, A. Nature (1999) [Pubmed]
  29. Identification of an angiogenic mitogen selective for endocrine gland endothelium. LeCouter, J., Kowalski, J., Foster, J., Hass, P., Zhang, Z., Dillard-Telm, L., Frantz, G., Rangell, L., DeGuzman, L., Keller, G.A., Peale, F., Gurney, A., Hillan, K.J., Ferrara, N. Nature (2001) [Pubmed]
  30. HIF-1 and mechanisms of hypoxia sensing. Semenza, G.L. Curr. Opin. Cell Biol. (2001) [Pubmed]
  31. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Tian, H., Hammer, R.E., Matsumoto, A.M., Russell, D.W., McKnight, S.L. Genes Dev. (1998) [Pubmed]
  32. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Van Dorpe, J., Hellings, P., Gorselink, M., Heymans, S., Theilmeier, G., Dewerchin, M., Laudenbach, V., Vermylen, P., Raat, H., Acker, T., Vleminckx, V., Van Den Bosch, L., Cashman, N., Fujisawa, H., Drost, M.R., Sciot, R., Bruyninckx, F., Hicklin, D.J., Ince, C., Gressens, P., Lupu, F., Plate, K.H., Robberecht, W., Herbert, J.M., Collen, D., Carmeliet, P. Nat. Genet. (2001) [Pubmed]
  33. S-nitrosothiols signal the ventilatory response to hypoxia. Lipton, A.J., Johnson, M.A., Macdonald, T., Lieberman, M.W., Gozal, D., Gaston, B. Nature (2001) [Pubmed]
  34. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Goldberg, M.A., Dunning, S.P., Bunn, H.F. Science (1988) [Pubmed]
  35. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Tian, H., McKnight, S.L., Russell, D.W. Genes Dev. (1997) [Pubmed]
  36. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. Lee, S.H., Wolf, P.L., Escudero, R., Deutsch, R., Jamieson, S.W., Thistlethwaite, P.A. N. Engl. J. Med. (2000) [Pubmed]
  37. Branching morphogenesis of the Drosophila tracheal system. Ghabrial, A., Luschnig, S., Metzstein, M.M., Krasnow, M.A. Annu. Rev. Cell Dev. Biol. (2003) [Pubmed]
  38. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Ravi, R., Mookerjee, B., Bhujwalla, Z.M., Sutter, C.H., Artemov, D., Zeng, Q., Dillehay, L.E., Madan, A., Semenza, G.L., Bedi, A. Genes Dev. (2000) [Pubmed]
  39. Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia. Pichiule, P., Chavez, J.C., Schmidt, A.M., Vannucci, S.J. J. Biol. Chem. (2007) [Pubmed]
  40. Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1. Sutton, K.M., Hayat, S., Chau, N.M., Cook, S., Pouyssegur, J., Ahmed, A., Perusinghe, N., Le Floch, R., Yang, J., Ashcroft, M. Oncogene (2007) [Pubmed]
  41. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M.C., Martelli, F. J. Biol. Chem. (2008) [Pubmed]
  42. Inflammatory cytokines and hypoxia contribute to 18F-FDG uptake by cells involved in pannus formation in rheumatoid arthritis. Matsui, T., Nakata, N., Nagai, S., Nakatani, A., Takahashi, M., Momose, T., Ohtomo, K., Koyasu, S. J. Nucl. Med. (2009) [Pubmed]
  43. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Shweiki, D., Itin, A., Soffer, D., Keshet, E. Nature (1992) [Pubmed]
  44. Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. Kuroki, M., Voest, E.E., Amano, S., Beerepoot, L.V., Takashima, S., Tolentino, M., Kim, R.Y., Rohan, R.M., Colby, K.A., Yeo, K.T., Adamis, A.P. J. Clin. Invest. (1996) [Pubmed]
  45. Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver. Lemasters, J.J., Stemkowski, C.J., Ji, S., Thurman, R.G. J. Cell Biol. (1983) [Pubmed]
  46. Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes. Zhou, X., Zhai, X., Ashraf, M. Circulation (1996) [Pubmed]
  47. Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. Noll, G., Wenzel, R.R., Schneider, M., Oesch, V., Binggeli, C., Shaw, S., Weidmann, P., Lüscher, T.F. Circulation (1996) [Pubmed]
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