Gene Review:
mbk-1 - Protein MBK-1
Caenorhabditis elegans
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Disease relevance of mbk-1
- The overexpression of DYRK1A in Down syndrome led us to examine the effects of overexpression of its C. elegans ortholog mbk-1 [1].
Psychiatry related information on mbk-1
- Using tissue-specific and inducible promoters, we show that additional copies of mbk-1 can impair olfaction cell-autonomously in mature, fully differentiated neurons and that this impairment is reversible [1].
High impact information on mbk-1
- We isolated deletion alleles in all three genes and show that loss of mbk-1, the gene most closely related to DYRK1A, causes no obvious defects, while another gene, mbk-2, is essential for viability [1].
- We found that animals containing additional copies of the mbk-1 gene display behavioral defects in chemotaxis toward volatile chemoattractants and that the extent of these defects correlates with mbk-1 gene dosage [1].
References
- Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Raich, W.B., Moorman, C., Lacefield, C.O., Lehrer, J., Bartsch, D., Plasterk, R.H., Kandel, E.R., Hobert, O. Genetics (2003) [Pubmed]
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