Gene Review:
hlh-14 - Protein HLH-14
Caenorhabditis elegans
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High impact information on hlh-14
- Finally, a reduction in the function of hlh-2, which encodes the C. elegans E/Daughterless bHLH homolog, results in similar neuron loss as hlh-14 mutants and enhances the effects of partially reducing hlh-14 function [1].
- Furthermore, neural loss in hlh-14 mutants results from a defect in an asymmetric cell division: the PVQ/HSN/PHB neuroblast inappropriately assumes characteristics of its sister cell, the hyp7/T blast cell [1].
- We find that a number of neuroblasts express HLH-14 in the C. elegans embryo, including the PVQ/HSN/PHB neuroblast, a cell that generates the PVQ interneuron, the HSN motoneuron and the PHB sensory neuron. hlh-14 mutants lack all three of these neurons [1].
References
- HLH-14 is a C. elegans achaete-scute protein that promotes neurogenesis through asymmetric cell division. Frank, C.A., Baum, P.D., Garriga, G. Development (2003) [Pubmed]
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