Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

smp-2 - Protein SMP-2

Caenorhabditis elegans

Dalpé, G. et al., Ginzburg, V.E. et al.

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High impact information on smp-2

We show genetically that plx-1 is part of the same functional pathway as smp-1 and smp-2 for male ray positioning [1].
Recent work in C. elegans showed that semaphorin 1 (smp-1 and smp-2) and plexin 1 (plx-1) are required to prevent anterior displacement of the ray 1 cells in the male tail (Fujii et al., 2002; Ginzburg et al., 2002) [1].

Other interactions of smp-2

We have isolated and characterized deletion mutants of C. elegans semaphorin 1a (Ce-sema-1a or smp-1) and semaphorin 1b (Ce-sema-1b or smp-2) genes [2].

References

Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans. Dalpé, G., Zhang, L.W., Zheng, H., Culotti, J.G. Development (2004) [Pubmed]
Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg, V.E., Roy, P.J., Culotti, J.G. Development (2002) [Pubmed]

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