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Gene Review:

smp-1 - Protein SMP-1

Caenorhabditis elegans

Ginzburg, V.E. et al., Liu, Z. et al., Dalpé, G. et al., Dalpé, G. et al.

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High impact information on smp-1

This smp-1- and plx-1-dependent process repeats until seven rings are stacked along the dorsoventral axis, creating a common vulva lumen [1].
We show genetically that plx-1 is part of the same functional pathway as smp-1 and smp-2 for male ray positioning [2].
A feature of smp-1 mutants that is shared with mutants of mab-20 (which encodes Sema-2a) is the abnormal perdurance of contacts between epidermal cells [3].
Both mutants also have defects in other aspects of epidermal functions, including head and tail epidermal morphogenesis and touch cell axon migration, whereas, smp-1 mutants alone have defects in defecation and brood size [3].
In plx-1 and smp-1 mutants, hermaphrodites sometimes exhibit a protruding vulva or multiple vulva-like protrusions [4].

Biological context of smp-1

The arrangement defects of VPCs in plx-1 and smp-1 mutants are rescued by expressing the respective cDNA in VPCs. plx-1::egfp and smp-1::egfp transgenes are both expressed in all vulval cells, including VPCs, throughout vulval development [4].

Other interactions of smp-1

We have isolated and characterized deletion mutants of C. elegans semaphorin 1a (Ce-sema-1a or smp-1) and semaphorin 1b (Ce-sema-1b or smp-2) genes [3].

References

Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline. Dalpé, G., Brown, L., Culotti, J.G. Development (2005) [Pubmed]
Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans. Dalpé, G., Zhang, L.W., Zheng, H., Culotti, J.G. Development (2004) [Pubmed]
Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg, V.E., Roy, P.J., Culotti, J.G. Development (2002) [Pubmed]
C. elegans PlexinA PLX-1 mediates a cell contact-dependent stop signal in vulval precursor cells. Liu, Z., Fujii, T., Nukazuka, A., Kurokawa, R., Suzuki, M., Fujisawa, H., Takagi, S. Dev. Biol. (2005) [Pubmed]

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AgaP_AGAP008656	Anopheles gambiae str. PEST
Sema-1a	Drosophila melanogaster

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