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Gene Review

Orc1  -  origin recognition complex, subunit 1

Mus musculus

Synonyms: AA545195, MmORC1, Orc1l, Origin recognition complex subunit 1
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High impact information on Orc1l

  • Immunoblotting analysis revealed that hamster Orc1 and Orc2 proteins were present in nuclei at equivalent concentrations throughout the cell cycle, but only Orc2 was stably bound to chromatin [1].
  • Since hamster Orc proteins are closely related to their human and mouse homologs, the unexpected behavior of hamster Orc1 provides a novel mechanism in mammals for delaying assembly of pre-replication complexes until mitosis is complete and a nuclear structure has formed [1].
  • ChIP assays revealed that both replication origins bind AlF-C and Orc1 [2].
  • The variant form of Orc1, Orc1B, lacks 35 amino acid residues in exon 5; the variant of Orc2, Orc2B, lacks 48 amino acid residues in exon 2 [3].

Analytical, diagnostic and therapeutic context of Orc1l

  • Chromatin immunoprecipitation (ChIP) assays indicated that the reduction of replicator activity was paralleled with the reduced binding of AlF-C and Orc1, suggesting that sequence-specific binding of AlF-C to the ectopic rat origin leads to enhanced replicator activity in cooperation with Orc1 [2].


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