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Gene Review

Orc2  -  origin recognition complex, subunit 2

Mus musculus

Synonyms: AU041563, Orc2l, Origin recognition complex subunit 2
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High impact information on Orc2l

  • Immunoblotting analysis revealed that hamster Orc1 and Orc2 proteins were present in nuclei at equivalent concentrations throughout the cell cycle, but only Orc2 was stably bound to chromatin [1].
  • The variant form of Orc1, Orc1B, lacks 35 amino acid residues in exon 5; the variant of Orc2, Orc2B, lacks 48 amino acid residues in exon 2 [2].
  • To define the physiological functions of the mammalian ORC, we cloned ORC subunit cDNAs from mouse NIH3T3 cells and found novel variant forms of Orc1, Orc2, and Orc3 each derived from alternative RNA splicing [2].
  • An in vitro phosphorylation assay showed that the Orc2 protein is a substrate of Plk1 [3].
  • Depletion of Orc2 and Mcm3 by siRNA leads to an inhibition of cell proliferation, an altered cell cycle distribution as well as to multinucleated cells with insufficiently organised microtubules [3].


  1. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. Natale, D.A., Li, C.J., Sun, W.H., DePamphilis, M.L. EMBO J. (2000) [Pubmed]
  2. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake, Y., Mizuno, T., Yanagi, K., Hanaoka, F. J. Biol. Chem. (2005) [Pubmed]
  3. Mouse pre-replicative complex proteins colocalise and interact with the centrosome. Stuermer, A., Hoehn, K., Faul, T., Auth, T., Brand, N., Kneissl, M., P??tter, V., Grummt, F. Eur. J. Cell Biol. (2007) [Pubmed]
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