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Gene Review:

old-2 - Protein OLD-2

Caenorhabditis elegans

Rikke, B.A. et al.

Rikke, Murakami, Johnson,

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High impact information on old-2

However, these families appeared to have split too early from the old-1/old-2 family to be orthologs, suggesting that a mammalian ortholog could yet be discovered [1].

Biological context of old-2

The tree includes a number of invertebrate receptor PTKs and a novel mammalian receptor PTK (inferred from the expressed-sequence tag database) that have not previously been analyzed. old-1 and old-2 were found to be members of a surprisingly large C. elegans PTK family having 16 members [1].

References

Paralogy and orthology of tyrosine kinases that can extend the life span of Caenorhabditis elegans. Rikke, B.A., Murakami, S., Johnson, T.E. Mol. Biol. Evol. (2000) [Pubmed]

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