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Gene Review

old-1  -  Protein OLD-1

Caenorhabditis elegans

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High impact information on old-1

  • Importantly, old-1 is required for the life extension of age-1 and daf-2 mutants [1].
  • Both RT-PCR and analysis of an OLD-1::GFP tag suggest that old-1 expression is dependent on daf-16 [1].
  • The transcription of old-1 is upregulated in long-lived age-1 and daf-2 mutants and is upregulated in response to heat, UV light, and starvation [1].
  • However, these families appeared to have split too early from the old-1/old-2 family to be orthologs, suggesting that a mammalian ortholog could yet be discovered [2].

Biological context of old-1

  • The tree includes a number of invertebrate receptor PTKs and a novel mammalian receptor PTK (inferred from the expressed-sequence tag database) that have not previously been analyzed. old-1 and old-2 were found to be members of a surprisingly large C. elegans PTK family having 16 members [2].
  • Two genes (daf-16 and old-1) are epistatic to the long-life phenotype of most mutants and also yield over-expression strains that are stress-resistant and long-lived [3].


  1. The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Murakami, S., Johnson, T.E. Curr. Biol. (2001) [Pubmed]
  2. Paralogy and orthology of tyrosine kinases that can extend the life span of Caenorhabditis elegans. Rikke, B.A., Murakami, S., Johnson, T.E. Mol. Biol. Evol. (2000) [Pubmed]
  3. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. Johnson, T.E., Henderson, S., Murakami, S., de Castro, E., de Castro, S.H., Cypser, J., Rikke, B., Tedesco, P., Link, C. J. Inherit. Metab. Dis. (2002) [Pubmed]
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