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Gene Review

Prok1  -  prokineticin 1

Rattus norvegicus

Synonyms: EG-VEGF, Endocrine-gland-derived vascular endothelial growth factor, Prokineticin-1
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Disease relevance of Prok1


High impact information on Prok1

  • The identification of the receptors for EG-VEGF/prokineticins may provide a novel molecular basis for the regulation of angiogenesis in endocrine glands [2].
  • Endocrine gland-derived vascular endothelial growth factor (EG-VEGF, identical to prokineticin 1) is a novel peptide recently identified as a selective mitogen for endocrine gland endothelial cells [2].


  1. Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8. Vellani, V., Colucci, M., Lattanzi, R., Giannini, E., Negri, L., Melchiorri, P., McNaughton, P.A. J. Neurosci. (2006) [Pubmed]
  2. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Masuda, Y., Takatsu, Y., Terao, Y., Kumano, S., Ishibashi, Y., Suenaga, M., Abe, M., Fukusumi, S., Watanabe, T., Shintani, Y., Yamada, T., Hinuma, S., Inatomi, N., Ohtaki, T., Onda, H., Fujino, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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