Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Nlrp1a - NLR family, pyrin domain containing 1A

Mus musculus

Synonyms: CARD7, DEFCAP, Gm14, Gm15, NAC, ...

Boyden, E.D. et al.

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Disease relevance of Nlrp1a

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin [1].

High impact information on Nlrp1a

We also show that LeTx-induced macrophage death requires caspase-1, which is activated in susceptible, but not resistant, macrophages after intoxication, suggesting that Nalp1b directly or indirectly activates caspase-1 in response to LeTx [1].

References

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Boyden, E.D., Dietrich, W.F. Nat. Genet. (2006) [Pubmed]

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