Gene Review:
Casp1 - caspase 1
Mus musculus
Synonyms:
CASP-1, Caspase-1, ICE, IL-1 beta-converting enzyme, IL-1BC, ...
Black,
Fang,
Nicholson,
Tracey,
Klender,
Ueda,
Elia,
Shelanski,
Ghayur,
Wang,
Dzietko,
Yeh,
Bittigau,
Zychlinsky,
Herzog,
Brown,
Talanian,
Rokutan,
Jang,
Singh,
Hui,
Calzascia,
Rabacchi,
Hao,
Paskind,
Quintal,
Crossman,
Ikonomidou,
Hersh,
Carter,
Ghori,
Chang,
Dhir,
Banerjee,
Obladen,
Hotchkiss,
Butler,
Mahler,
King,
Kamen,
Okada,
Sekiyama,
Falkow,
Hugunin,
Bührer,
Dower,
Kashiwamura,
Tripathi,
Roy,
Swanson,
Takeda,
Grimm,
Chang,
Vogel,
Xiao,
Frappier,
Ohashi,
Karl,
Mak,
Aspiotis,
Han,
Sekut,
Zeng,
Sekiyama,
Duncan,
Chamberlain,
Leineweber,
Bouley,
Allen,
Polley,
Francis,
Baier,
Evans,
You-Ten,
Felderhoff-Mueser,
Wakeham,
Xanthoudakis,
Friedman,
Tinsley,
Troy,
Monack,
Sifringer,
Okamura,
Nelson,
Dewberry,
Wong,
- Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., McDowell, J., Paskind, M., Rodman, L., Salfeld, J. Cell (1995)
- Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Sutterwala, F.S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G.S., Grant, E.P., Bertin, J., Coyle, A.J., Galán, J.E., Askenase, P.W., Flavell, R.A. Immunity (2006)
- Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Sansonetti, P.J., Phalipon, A., Arondel, J., Thirumalai, K., Banerjee, S., Akira, S., Takeda, K., Zychlinsky, A. Immunity (2000)
- Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Hotchkiss, R.S., Chang, K.C., Swanson, P.E., Tinsley, K.W., Hui, J.J., Klender, P., Xanthoudakis, S., Roy, S., Black, C., Grimm, E., Aspiotis, R., Han, Y., Nicholson, D.W., Karl, I.E. Nat. Immunol. (2000)
- Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Hermel, E., Gafni, J., Propp, S.S., Leavitt, B.R., Wellington, C.L., Young, J.E., Hackam, A.S., Logvinova, A.V., Peel, A.L., Chen, S.F., Hook, V., Singaraja, R., Krajewski, S., Goldsmith, P.C., Ellerby, H.M., Hayden, M.R., Bredesen, D.E., Ellerby, L.M. Cell Death Differ. (2004)
- Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Lu, D.C., Shaked, G.M., Masliah, E., Bredesen, D.E., Koo, E.H. Ann. Neurol. (2003)
- The central effectors of cell death in the immune system. Rathmell, J.C., Thompson, C.B. Annu. Rev. Immunol. (1999)
- Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Boyden, E.D., Dietrich, W.F. Nat. Genet. (2006)
- Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Hao, Z., Duncan, G.S., Chang, C.C., Elia, A., Fang, M., Wakeham, A., Okada, H., Calzascia, T., Jang, Y., You-Ten, A., Yeh, W.C., Ohashi, P., Wang, X., Mak, T.W. Cell (2005)
- Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model. Monack, D.M., Hersh, D., Ghori, N., Bouley, D., Zychlinsky, A., Falkow, S. J. Exp. Med. (2000)
- Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Le, D.A., Wu, Y., Huang, Z., Matsushita, K., Plesnila, N., Augustinack, J.C., Hyman, B.T., Yuan, J., Kuida, K., Flavell, R.A., Moskowitz, M.A. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia. Joshi, V.D., Kalvakolanu, D.V., Hebel, J.R., Hasday, J.D., Cross, A.S. Infect. Immun. (2002)
- Genetic Susceptibility and Caspase Activation in Mouse and Human Macrophages Are Distinct for Legionella longbeachae and L. pneumophila. Asare, R., Santic, M., Gobin, I., Doric, M., Suttles, J., Graham, J.E., Price, C.D., Abu Kwaik, Y. Infect. Immun. (2007)
- Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Singh, S.V., Zeng, Y., Xiao, D., Vogel, V.G., Nelson, J.B., Dhir, R., Tripathi, Y.B. Mol. Cancer Ther. (2005)
- Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Miwa, K., Asano, M., Horai, R., Iwakura, Y., Nagata, S., Suda, T. Nat. Med. (1998)
- A stress-induced, superoxide-mediated caspase-1 activation pathway causes plasma IL-18 upregulation. Sekiyama, A., Ueda, H., Kashiwamura, S., Sekiyama, R., Takeda, M., Rokutan, K., Okamura, H. Immunity (2005)
- Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. Melnikov, V.Y., Ecder, T., Fantuzzi, G., Siegmund, B., Lucia, M.S., Dinarello, C.A., Schrier, R.W., Edelstein, C.L. J. Clin. Invest. (2001)
- Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Zhang, W.H., Wang, X., Narayanan, M., Zhang, Y., Huo, C., Reed, J.C., Friedlander, R.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Kothakota, S., Azuma, T., Reinhard, C., Klippel, A., Tang, J., Chu, K., McGarry, T.J., Kirschner, M.W., Koths, K., Kwiatkowski, D.J., Williams, L.T. Science (1997)
- An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity. Fiorucci, S., Mencarelli, A., Palazzetti, B., Del Soldato, P., Morelli, A., Ignarro, L.J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Interferon-gamma-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members. Rathbun, R.K., Christianson, T.A., Faulkner, G.R., Jones, G., Keeble, W., O'Dwyer, M., Bagby, G.C. Blood (2000)
- Caspase-2 mediates neuronal cell death induced by beta-amyloid. Troy, C.M., Rabacchi, S.A., Friedman, W.J., Frappier, T.F., Brown, K., Shelanski, M.L. J. Neurosci. (2000)
- Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Hentze, H., Lin, X.Y., Choi, M.S., Porter, A.G. Cell Death Differ. (2003)
- Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing. Squires, R.C., Muehlbauer, S.M., Brojatsch, J. J. Biol. Chem. (2007)
- Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis. Carson, C., Saleh, M., Fung, F.W., Nicholson, D.W., Roskams, A.J. J. Neurosci. (2005)
- Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. Dufner, A., Pownall, S., Mak, T.W. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. Wellington, C.L., Ellerby, L.M., Gutekunst, C.A., Rogers, D., Warby, S., Graham, R.K., Loubser, O., van Raamsdonk, J., Singaraja, R., Yang, Y.Z., Gafni, J., Bredesen, D., Hersch, S.M., Leavitt, B.R., Roy, S., Nicholson, D.W., Hayden, M.R. J. Neurosci. (2002)
- Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. Kahlenberg, J.M., Lundberg, K.C., Kertesy, S.B., Qu, Y., Dubyak, G.R. J. Immunol. (2005)
- Poly(ADP-ribose)polymerase activation mediates lung epithelial cell death in vitro but is not essential in hyperoxia-induced lung injury. Pagano, A., Pitteloud, C., Reverdin, C., Métrailler-Ruchonnet, I., Donati, Y., Barazzone Argiroffo, C. Am. J. Respir. Cell Mol. Biol. (2005)
- In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline. Involvement of caspase cascades and IkappaBalpha phosphorylation. Lerma-Díaz, J.M., Hernández-Flores, G., Domínguez-Rodríguez, J.R., Ortíz-Lazareno, P.C., Gómez-Contreras, P., Cervantes-Munguía, R., Scott-Algara, D., Aguilar-Lemarroy, A., Jave-Suárez, L.F., Bravo-Cuellar, A. Immunol. Lett. (2006)
- Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. Haraguchi, M., Torii, S., Matsuzawa, S., Xie, Z., Kitada, S., Krajewski, S., Yoshida, H., Mak, T.W., Reed, J.C. J. Exp. Med. (2000)
- Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). Kim, Y.M., Talanian, R.V., Li, J., Billiar, T.R. J. Immunol. (1998)
- Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. Tsujimoto, K., Ono, T., Sato, M., Nishida, T., Oguma, T., Tadakuma, T. J. Biol. Chem. (2005)
- Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. Lin, X.Y., Choi, M.S., Porter, A.G. J. Biol. Chem. (2000)
- Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. Franchi, L., Kanneganti, T.D., Dubyak, G.R., Núñez, G. J. Biol. Chem. (2007)
- Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., Wong, W., Kamen, R., Tracey, D., Allen, H. Nature (1997)
- Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease. Starcevic, S.L., Elferink, C., Novak, R.F. J. Natl. Cancer Inst. (2001)
- Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Puren, A.J., Fantuzzi, G., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase-dependent pathway. Yadav, S.S., Sindram, D., Perry, D.K., Clavien, P.A. Hepatology (1999)
- Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Felderhoff-Mueser, U., Sifringer, M., Polley, O., Dzietko, M., Leineweber, B., Mahler, L., Baier, M., Bittigau, P., Obladen, M., Ikonomidou, C., Bührer, C. Ann. Neurol. (2005)
- Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Chamberlain, J., Evans, D., King, A., Dewberry, R., Dower, S., Crossman, D., Francis, S. Am. J. Pathol. (2006)