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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DTX3  -  deltex 3, E3 ubiquitin ligase

Homo sapiens

Synonyms: Deltex3, FLJ34766, Protein deltex-3, RING finger protein 154, RNF154, ...
 
 
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High impact information on DTX3

  • Among them, Okadaic acid (OA), Dinophysistoxin 1 (DTX-1, 35-methyl OA), Dinophysistoxin 2 (DTX-2, OA isomers) and Dinophysistoxin 3 (DTX-3, 7-O-acyl-35-methyl OA), all of which have free carboxilic groups [1].
  • However, the OA/DTX2 ratio in the DTX3 conjugated form was different, with OA being the most abundant in all cases [2].
  • Base hydrolysis of DTX3 toxins gave free OA and DTX2, which were determined following ADAM derivatization [2].
  • A human diarrhetic poisoning (DSP) incident with Donax clams (Donax trunculus) harvested at Fuzeta (Algarve coast) was confirmed where the apolar (DTX-3 type) and other esters remaining in the polar aqueous methanol layer were implicated [3].

References

  1. Quantitation of diarrhetic shellfish poisoning toxins in Chilean mussel using pyrenyldiazomethane as fluorescent labeling reagent. García, C., Pereira, P., Valle, L., Lagos, N. Biol. Res. (2003) [Pubmed]
  2. Further studies on the analysis of DSP toxin profiles in galician mussels. Comesaña Losada, M., Leão, J.M., Gago-Martínez, A., Rodríguez Vázquez, J.A., Quilliam, M.A. J. Agric. Food Chem. (1999) [Pubmed]
  3. Esters of okadaic acid and dinophysistoxin-2 in Portuguese bivalves related to human poisonings. Vale, P., Sampayo, M.A. Toxicon (1999) [Pubmed]
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