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Gene Review

FUK  -  fucokinase

Homo sapiens

Synonyms: FLJ39408, Fucokinase, L-fucose kinase
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Disease relevance of FUK

  • Fucokinase full-length protein and a deletion mutant lacking the first 363 amino acids of the N-terminus were expressed in Escherichia coli BL21 cells [1].

High impact information on FUK


Associations of FUK with chemical compounds

  • Fucokinase phosphorylates L-fucose at the anomeric position and, as such, might use either the alpha or beta anomer as its substrate [4].


  1. Identification of human L-fucose kinase amino acid sequence. Hinderlich, S., Berger, M., Blume, A., Chen, H., Ghaderi, D., Bauer, C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII. Niittymäki, J., Mattila, P., Renkonen, R. APMIS (2006) [Pubmed]
  3. Activity of enzymes catalyzing formation of beta-L-fucosyl phosphate and GDP-beta-L-fucose in amphibian tissues and their application in chemo-enzymic synthesis of GDP-beta-L-fucose. Druzhinina, T.N., Utkina, N.S., Chan, K., Strecker, G., Shibaev, V.N. Biochemistry Mosc. (1999) [Pubmed]
  4. Fucokinase, its anomeric specificity and mechanism of phosphate group transfer. Butler, W., Serif, G.S. Biochim. Biophys. Acta (1985) [Pubmed]
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