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Gene Review:

DHFRL1 - dihydrofolate reductase-like 1

Homo sapiens

Synonyms: DHFRP4, Dihydrofolate reductase, mitochondrial, Dihydrofolate reductase-like protein 1, FLJ16119

Schultz, R.M. et al., Anagnou, N.P. et al.

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High impact information on DHFRL1

The functional DHFR gene is on chromosome 5, and DHFRP4 is on chromosome 3 [1].
The cells either demonstrated a GARFT-like reversal pattern (complete protection by hypoxanthine) for GC3MTA or a dihydrofolate reductase-like reversal pattern (complete protection by the combination of hypoxanthine and thymidine) for HCT-8MTA and CCRF-CEM(MTA) cells [2].

References

Chromosomal localization and racial distribution of the polymorphic human dihydrofolate reductase pseudogene (DHFRP1). Anagnou, N.P., Antonarakis, S.E., O'Brien, S.J., Modi, W.S., Nienhuis, A.W. Am. J. Hum. Genet. (1988) [Pubmed]
Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs. Schultz, R.M., Chen, V.J., Bewley, J.R., Roberts, E.F., Shih, C., Dempsey, J.A. Semin. Oncol. (1999) [Pubmed]

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