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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LGI3  -  leucine-rich repeat LGI family, member 3

Homo sapiens

Synonyms: LGI1-like protein 4, LGIL4, Leucine-rich glioma-inactivated protein 3, Leucine-rich repeat LGI family member 3, UNQ8190/PRO23199
 
 
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High impact information on LGI3

  • LGI family members, LGI3, LGI4 and a newly identified splice form of LGI2, LGI2B, are also secreted in culture, indicating that secretion is a conserved feature of this protein family [1].
  • In silico mapping and radiation hybrid experiments assigned LGI2, LGI3, and LGI4 to different chromosomal regions (4p15.2, 8p21.3, 19q13.11), some of which have been implicated in epileptogenesis and/or tumorigenesis [2].

References

  1. ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy. Senechal, K.R., Thaller, C., Noebels, J.L. Hum. Mol. Genet. (2005) [Pubmed]
  2. The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. Gu, W., Wevers, A., Schröder, H., Grzeschik, K.H., Derst, C., Brodtkorb, E., de Vos, R., Steinlein, O.K. FEBS Lett. (2002) [Pubmed]
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