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Gene Review

LGI2  -  leucine-rich repeat LGI family, member 2

Homo sapiens

Synonyms: FLJ10675, KIAA1916, LGI1-like protein 2, LGIL2, Leucine-rich glioma-inactivated protein 2, ...
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High impact information on LGI2

  • Genetic and expression analyses of all five zebrafish lgi genes revealed duplications of lgi1 and lgi2, each resulting in two paralogous gene copies with mostly nonoverlapping expression patterns [1].
  • In silico mapping and radiation hybrid experiments assigned LGI2, LGI3, and LGI4 to different chromosomal regions (4p15.2, 8p21.3, 19q13.11), some of which have been implicated in epileptogenesis and/or tumorigenesis [2].
  • No mutations in LGI2, LGI3, or LGI4 were found in the other two ADPEAF families [3].


  1. Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders. Gu, W., Gibert, Y., Wirth, T., Elischer, A., Bloch, W., Meyer, A., Steinlein, O.K., Begemann, G. Mol. Biol. Evol. (2005) [Pubmed]
  2. The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. Gu, W., Wevers, A., Schröder, H., Grzeschik, K.H., Derst, C., Brodtkorb, E., de Vos, R., Steinlein, O.K. FEBS Lett. (2002) [Pubmed]
  3. LGI1 mutations in temporal lobe epilepsies. Berkovic, S.F., Izzillo, P., McMahon, J.M., Harkin, L.A., McIntosh, A.M., Phillips, H.A., Briellmann, R.S., Wallace, R.H., Mazarib, A., Neufeld, M.Y., Korczyn, A.D., Scheffer, I.E., Mulley, J.C. Neurology (2004) [Pubmed]
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