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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC44A5  -  solute carrier family 44, member 5

Homo sapiens

Synonyms: CTL5, Choline transporter-like protein 5, MGC34032, Solute carrier family 44 member 5
 
 
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Disease relevance of SLC44A5

  • The restriction element identified for CTL 5/30 was HLA-A2, as shown by blocking of cytotoxicity using an anti-HLA-A2 monoclonal antibody (MAb) and by resistance of an HLA-A2-negative melanoma variant SK29-MEL [1].
 

High impact information on SLC44A5

  • Peptides eluted from allogeneic HLA-A2-matched RCC and melanoma cell lines exhibited the CTL-5-defined epitope in the same HPLC fractions as peptides derived from the autologous RCC line [2].
  • Peptides were acideulated from various cell lines, separated by reversed phase high performance liquid chromatography (RP-HPLC), and assessed for their ability to reconstitute the CTL-5-defined epitope by pulsing the peptides on HLA-A2 positive antigen-processing mutant cell line CEM x 721.174.T2 (T2) [2].

References

  1. Cellular immune response to human renal-cell carcinomas: definition of a common antigen recognized by HLA-A2-restricted cytotoxic T-lymphocyte (CTL) clones. Bernhard, H., Karbach, J., Wölfel, T., Busch, P., Störkel, S., Stöckle, M., Wölfel, C., Seliger, B., Huber, C., Meyer zum Büschenfelde, K.H. Int. J. Cancer (1994) [Pubmed]
  2. Recognition of human renal cell carcinoma and melanoma by HLA-A2-restricted cytotoxic T lymphocytes is mediated by shared peptide epitopes and up-regulated by interferon-gamma. Bernhard, H., Maeurer, M.J., Jäger, E., Wölfel, T., Schneider, J., Karbach, J., Seliger, B., Huber, C., Storkus, W.S., Lotze, M.T., Meyer zum Büschenfelde, K.H., Knuth, A. Scand. J. Immunol. (1996) [Pubmed]
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