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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ube2o  -  ubiquitin-conjugating enzyme E2O

Mus musculus

Synonyms: 9630022H21, B230113M03Rik, E2-230K, E2/E3 hybrid ubiquitin-protein ligase UBE2O, Kiaa1734, ...
 
 
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High impact information on Ube2o

  • In contrast to most proteins induced in reticulocytes, E2-20K and E2-230K enzymes are present at strongly reduced levels in erythrocytes and thus decline in abundance as reticulocyte maturation is completed [1].
  • Induction of the E2-20K and E2-230K genes is specific, as transcript levels for at least two other ubiquitinating enzymes fall during erythroblast differentiation [1].
  • E2-20K and E2-230K, which are abundant in reticulocytes, were low or absent in undifferentiated and differentiated MEL cells [2].

References

  1. Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. Wefes, I., Mastrandrea, L.D., Haldeman, M., Koury, S.T., Tamburlin, J., Pickart, C.M., Finley, D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Dynamics of ubiquitin conjugation during erythroid differentiation in vitro. Haldeman, M.T., Finley, D., Pickart, C.M. J. Biol. Chem. (1995) [Pubmed]
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