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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Reticulocytes


High impact information on Reticulocytes

  • Silenced LOX mRNA in rabbit reticulocytes specifically coimmunoprecipitated with hnRNP K [6].
  • We have purified two proteins from rabbit reticulocytes that specifically mediate LOX silencing and identified them as hnRNPs K and E1 [6].
  • In vitro experiments with a fusion construct using reticulocyte lysates demonstrate polyamine-dependent expression with a frameshift efficiency of 19% at the optimal concentration of spermidine [7].
  • There was a 28 percent increase in the number of reticulocytes containing fetal hemoglobin and a 48 percent increase in the percentage of fetal hemoglobin, as compared with the maximal values obtained with hydroxyurea alone [8].
  • Treatment with erythropoietin, either alone or in combination with hydroxyurea, had no significant effect on the percentage of hemoglobin F-containing reticulocytes (F reticulocytes) or red cells (F cells) [9].

Chemical compound and disease context of Reticulocytes


Biological context of Reticulocytes


Anatomical context of Reticulocytes


Associations of Reticulocytes with chemical compounds


Gene context of Reticulocytes

  • In the rad6 delta 1-9 mutant, beta-galactosidase proteins bearing destabilizing amino-terminal residues become long lived, and purified rad6 delta 1-9 protein is ineffective in ubiquitin-protein ligase (E3)-dependent protein degradation in the proteolytic system derived from rabbit reticulocytes [29].
  • Sequence analysis using PCR-amplified cDNA revealed that the 5'-end of the coding sequence of G6PD mRNA in reticulocytes is identical to those in other tissues [30].
  • In contrast, PMN and MNL IL-1 alpha and beta mRNAs were translated with equal efficiency in rabbit reticulocyte lysates, suggesting that synthesis of IL-1 in PMN is subject to some form of translational control [31].
  • Curcumin, a CSN kinase inhibitor, blocks E6-dependent p53 degradation in reticulocyte lysates [32].
  • Mutation of Thr155 to valine is sufficient to stabilize p53 against E6-dependent degradation in reticulocyte lysates and to reduce binding to Mdm2 [32].

Analytical, diagnostic and therapeutic context of Reticulocytes


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  10. Natural UAG suppressor glutamine tRNA is elevated in mouse cells infected with Moloney murine leukemia virus. Kuchino, Y., Beier, H., Akita, N., Nishimura, S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
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  12. Human red cell membrane adenylate cyclase in normal subjects and patients with hereditary spherocytosis, sickle cell disease and unidentified hemolytic anemias. Piau, J.P., Delaunay, J., Fischer, S., Tortolero, M., Schapira, G. Blood (1980) [Pubmed]
  13. Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen. Broudy, V.C., Lin, N.L., Priestley, G.V., Nocka, K., Wolf, N.S. Blood (1996) [Pubmed]
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  15. Hemolytic anemia and erythroleukemia, two distinct pathogenic effects of Friend MuLV: mapping of the effects to different regions of the viral genome. Sitbon, M., Sola, B., Evans, L., Nishio, J., Hayes, S.F., Nathanson, K., Garon, C.F., Chesebro, B. Cell (1986) [Pubmed]
  16. Loss of adhesion of murine erythroleukemia cells to fibronectin during erythroid differentiation. Patel, V.P., Lodish, H.F. Science (1984) [Pubmed]
  17. Effects of recombinant human granulocyte-macrophage colony-stimulating factor on myelosuppression induced by multiple cycles of high-dose chemotherapy in patients with advanced breast cancer. Hoekman, K., Wagstaff, J., van Groeningen, C.J., Vermorken, J.B., Boven, E., Pinedo, H.M. J. Natl. Cancer Inst. (1991) [Pubmed]
  18. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. Harding, C., Heuser, J., Stahl, P. J. Cell Biol. (1983) [Pubmed]
  19. General RNA binding proteins render translation cap dependent. Svitkin, Y.V., Ovchinnikov, L.P., Dreyfuss, G., Sonenberg, N. EMBO J. (1996) [Pubmed]
  20. Many cytoskeletal proteins associate with the hela cytoskeleton during translation in vitro. Fulton, A.B., Wan, K.M. Cell (1983) [Pubmed]
  21. Enhanced expression of H-2K and H-2D antigens on reticulocytes infected with Plasmodium yoelii. Jayawardena, A.N., Mogil, R., Murphy, D.B., Burger, D., Gershon, R.K. Nature (1983) [Pubmed]
  22. Evidence for role of m7G5'-phosphate group in recognition of eukaryotic mRNA by initiation factor IF-M3. Shafritz, D.A., Weinstein, J.A., Safer, B., Merrick, W.C., Weber, L.A., Hickey, E.D., Baglioni, C. Nature (1976) [Pubmed]
  23. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Koury, M.J., Bondurant, M.C. Science (1990) [Pubmed]
  24. Action of erythropoietin in vitro on rabbit reticulocyte membrane Ca2+-ATPase activity. Lawrence, W.D., Davis, P.J., Blas, S.D. J. Clin. Invest. (1987) [Pubmed]
  25. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Pan, B.T., Johnstone, R.M. Cell (1983) [Pubmed]
  26. Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea. Veith, R., Galanello, R., Papayannopoulou, T., Stamatoyannopoulos, G. N. Engl. J. Med. (1985) [Pubmed]
  27. Role for the adenosine triphosphate-dependent proteolytic pathway in reticulocyte maturation. Boches, F.S., Goldberg, A.L. Science (1982) [Pubmed]
  28. Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Strittmatter, W.J., Hirata, F., Axelrod, J. Science (1979) [Pubmed]
  29. The extremely conserved amino terminus of RAD6 ubiquitin-conjugating enzyme is essential for amino-end rule-dependent protein degradation. Watkins, J.F., Sung, P., Prakash, S., Prakash, L. Genes Dev. (1993) [Pubmed]
  30. Alternative splicing of human glucose-6-phosphate dehydrogenase messenger RNA in different tissues. Hirono, A., Beutler, E. J. Clin. Invest. (1989) [Pubmed]
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  32. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Bech-Otschir, D., Kraft, R., Huang, X., Henklein, P., Kapelari, B., Pollmann, C., Dubiel, W. EMBO J. (2001) [Pubmed]
  33. Primary structure and domain organization of human alpha and beta adducin. Joshi, R., Gilligan, D.M., Otto, E., McLaughlin, T., Bennett, V. J. Cell Biol. (1991) [Pubmed]
  34. DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism. Lim, F., Kraut, N., Framptom, J., Graf, T. EMBO J. (1992) [Pubmed]
  35. Effect of estrogen on gene expression: purification of vitellogenin messenger RNA. Wetekam, W., Mullinix, K.P., Deeley, R.G., Kronenberg, H.M., Eldridge, J.D., Meyers, M., Goldberger, R.F. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
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  37. Competitive advantage of diferric transferrin in delivering iron to reticulocytes. Huebers, H.A., Csiba, E., Huebers, E., Finch, C.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
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