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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SAMD9L  -  sterile alpha motif domain containing 9-like

Homo sapiens

Synonyms: C7orf6, DRIF2, FLJ39885, KIAA2005, SAM domain-containing protein 9-like, ...
 
 
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High impact information on SAMD9L

  • The UEF-1 and -3 sites in the uPA enhancer are highly conserved between species [1].
  • We have identified putative binding sites for UEF-1, -2 and -3 [1].
  • Introduction of these and other mutations in the context of the urokinase enhancer showed that all uCOM sites are important for enhancer activity but that UEF-4 and UEF-1 plus UEF-2/3 can substitute for each other, suggesting functional redundancy of urokinase enhancer factors [2].
  • The COM region contains binding sites for four different unidentified urokinase-type plasminogen activator enhancer factors (UEF 1 to 4), all four required for correct COM activity [3].

References

  1. A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells. Nerlov, C., De Cesare, D., Pergola, F., Caracciolo, A., Blasi, F., Johnsen, M., Verde, P. EMBO J. (1992) [Pubmed]
  2. Characterization of UEF-4, a DNA-binding protein required for transcriptional synergism between two AP-1 sites in the human urokinase enhancer. De Cesare, D., Palazzolo, M., Berthelsen, J., Blasi, F. J. Biol. Chem. (1997) [Pubmed]
  3. Purification and characterization of UEF3, a novel factor involved in the regulation of the urokinase and other AP-1 controlled promoters. Berthelsen, J., Vandekerkhove, J., Blasi, F. J. Biol. Chem. (1996) [Pubmed]
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