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Gene Review:

FAT2 - FAT atypical cadherin 2

Homo sapiens

Synonyms: CDHF8, CDHR9, Cadherin family member 8, HFAT2, KIAA0811, ...

Katoh, Y. et al., Jean, J.C. et al., Boultwood, J. et al.

Boultwood, Fidler, Strickson, Watkins, Gama, Kearney, Tosi, Kasprzyk, Cheng, Jaju, Wainscoat,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FAT2

FAT2 mRNA was expressed in infant brain, cerebellum, gastric cancer, pancreatic cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer [1].

High impact information on FAT2

A number of the genes assigned to the CDR represent good candidates for the 5q- syndrome, including MEGF1, G3BP, and several of the novel gene predictions [2].
We identified rat developing arteries and neural crest derivatives with multiple epidermal growth factor-like domains (DANCE) as a developmentally regulated gene using suppression-subtractive hybridization [3].
Domain architecture comparison and phylogenetic analysis revealed that FAT1, FAT2 and FAR3 were divergent from FAT4 [1].

References

Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome. Boultwood, J., Fidler, C., Strickson, A.J., Watkins, F., Gama, S., Kearney, L., Tosi, S., Kasprzyk, A., Cheng, J.F., Jaju, R.J., Wainscoat, J.S. Blood (2002) [Pubmed]
DANCE in developing and injured lung. Jean, J.C., Eruchalu, I., Cao, Y.X., Joyce-Brady, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]

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FAT2	Bos taurus
FAT2	Canis lupus familiaris
fat2	Danio rerio
FAT2	Gallus gallus
FAT2	Macaca mulatta
Fat2	Mus musculus
FAT2	Pan troglodytes
Fat2	Rattus norvegicus
fat2	Xenopus (Silurana) tropicalis

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