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MeSH Review

Neural Crest

 
 
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Disease relevance of Neural Crest

 

Psychiatry related information on Neural Crest

 

High impact information on Neural Crest

  • Analysis of microarray data from human nevi shows that the expression pattern of Slug, a master regulator of neural crest cell specification and migration, correlates with those of other genes that are important for neural crest cell migrations during development [9].
  • These results establish a new and essential role for Nf1 in endothelial cells and confirm the requirement for neurofibromin in the neural crest [10].
  • SIP1 seems to have crucial roles in normal embryonic neural and neural crest development [11].
  • Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator [12].
  • These results therefore indicate an essential stage- and tissue-specific role for Crkol in the function, differentiation, and/or survival of neural crest cells during development [13].
 

Chemical compound and disease context of Neural Crest

 

Biological context of Neural Crest

  • The observed defects are consistent with abnormalities in the survival and/or migration of cardiac neural crest early in embryogenesis and establish an essential role for neurotrophin 3 in regulating the development of the mammalian heart [19].
  • Using a positional candidacy strategy, we mapped TFAP2B, encoding a transcription factor expressed in neural crest cells, to the Char syndrome critical region and identified missense mutations altering conserved residues in two affected families [20].
  • Here we show that frog Zic2 encodes a zinc-finger transcription factor of the Gli superfamily which is expressed in stripes that alternate with those in which primary neurons differentiate and overlap the domains of floorplate and neural crest progenitors [21].
  • Important progress has been made in dissecting the roles of bone morphogenetic protein, Wnt and Notch signalling systems and their associated downstream transcription factors in the control of neural crest cell differentiation [22].
  • Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development [23].
 

Anatomical context of Neural Crest

 

Associations of Neural Crest with chemical compounds

  • It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations [28].
  • Xotch delta E inhibits the early expression of epidermal and neural crest markers yet enhances and extends the response of animal caps to mesodermal and neural induction [29].
  • Acetylcholine synthesis by mesencephalic neural crest cells in the process of migration in vivo [30].
  • Inhibition of neural crest cell attachment by integrin antisense oligonucleotides [31].
  • The mammalian transcription factor AP-2 is a sequence-specific DNA-binding protein expressed in neural crest lineages and regulated by retinoic acid [32].
 

Gene context of Neural Crest

  • The identification of Sox10 as the gene mutated in Dom mice (B.H. et al., manuscript submitted) prompted us to analyse the role of its human homologue SOX10 in neural crest defects [33].
  • As enteric neurons are derived from the vagal neural crest, HSCR is regarded as a neurocristopathy [34].
  • Deficiency in neurofibromin (encoded by Nf1) in mice results in mid-embryonic lethality owing to cardiac abnormalities previously thought to be secondary to cardiac neural-crest defects [10].
  • In Xenopus embryos, LRP6 activated Wnt-Fz signalling, and induced Wnt responsive genes, dorsal axis duplication and neural crest formation [35].
  • Pax7 can substitute for Pax3 function in dorsal neural tube, neural crest cell, and somite development, but not in the formation of muscles involving long-range migration of muscle progenitor cells [36].
 

Analytical, diagnostic and therapeutic context of Neural Crest

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