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Gene Review

Eif4h  -  eukaryotic translation initiation factor 4H

Mus musculus

Synonyms: AU018978, D5Ertd355e, E430026L18Rik, Ef4h, Eukaryotic translation initiation factor 4H, ...
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High impact information on Eif4h

  • The translation initiation factor eIF4A is the prototypical DEAD-box RNA helicase that works in conjunction with eIF4B and eIF4H and as a subunit of eIF4F to prepare the mRNA template for ribosome binding, possibly by unwinding the secondary structure proximal to the 5' m7GpppN cap structure [1].


  1. Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Bordeleau, M.E., Matthews, J., Wojnar, J.M., Lindqvist, L., Novac, O., Jankowsky, E., Sonenberg, N., Northcote, P., Teesdale-Spittle, P., Pelletier, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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