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Gene Review

EIF4H  -  eukaryotic translation initiation factor 4H

Homo sapiens

Synonyms: Eukaryotic translation initiation factor 4H, KIAA0038, WBSCR1, WSCR1, Williams-Beuren syndrome chromosomal region 1 protein, ...
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Disease relevance of EIF4H


High impact information on EIF4H

  • Also examined is the influence of ancillary protein factors (eIF4B, eIF4G, and eIF4H) on this activity [3].
  • The combinations of eIF4A, eIF4A + eIF4B, eIF4A + eIF4H, and eIF4F showed differences in their ability to unwind chemically modified duplexes [4].
  • Functional studies have revealed that recombinant heIF4H functions identically to rabbit eIF4H in stimulating protein synthesis, and the ATP hydrolysis and helicase activities of eIF4A [5].
  • Recombinant human eIF4H (heIF4H) was purified to greater than 95% homogeneity and shown to have similar physical characteristics to eIF4H purified from rabbit reticulocyte lysate as described previously [5].
  • Three tryptic fragments of eIF4H yielded amino acid sequences that were 100% identical to a human sequence found in the GeneBankTM that codes for a previously uncharacterized protein (HUMORFU_1) [6].

Biological context of EIF4H

  • In one patient with uncomplicated disease, HBV DNA was integrated into host chromosome 7 q11.23 in the WBSCR1 gene [7].
  • mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A [8].
  • Vhs interacts with the cellular translation initiation factor eIF4H, and several point mutations that abolish its mRNA degradative activity also abrogate its ability to bind eIF4H [8].
  • Further mapping by loss of heterozygosity analysis both by microsatellite marker and SNP profiling demonstrated a 1.5 Mb deletion beyond the telomeric end of the typical WSCR [2].

Associations of EIF4H with chemical compounds

  • The calculated molecular weight of the protein encoded by this sequence, its predicted cyanogen bromide fragmentation, and calculated isoelectric point are all consistent with those determined experimentally for eIF4H [6].
  • This interaction was verified by glutathione S-transferase pull-down experiments and by coimmunoprecipitation of Vhs and epitope-tagged eIF4H from extracts of mammalian cells [9].

Other interactions of EIF4H

  • LIMK1 and WSCR1 may be particularly relevant when explaining cognitive defects observed in WS patients [10].
  • Within this region we have completely characterized 200 kb containing the genes LIMK1, WBSCR1, and RFC2 [11].
  • Activity was strongly enhanced by the addition of RRL, eIF4H, or the related translation factor eIF4B [1].
  • Previous work has shown that vhs forms a complex with translation initiation factor eIF4H, which displays detectable RNase activity in the absence of other viral or host proteins [1].
  • Interestingly, only isoform 1 of two transcript variants of eukaryotic translation initiation factor 4H was greatly up-regulated in most of the tumor tissues [12].

Analytical, diagnostic and therapeutic context of EIF4H


  1. Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H. Doepker, R.C., Hsu, W.L., Saffran, H.A., Smiley, J.R. J. Virol. (2004) [Pubmed]
  2. Periventricular nodular heterotopia and Williams syndrome. Ferland, R.J., Gaitanis, J.N., Apse, K., Tantravahi, U., Walsh, C.A., Sheen, V.L. Am. J. Med. Genet. A (2006) [Pubmed]
  3. eIF4A: the godfather of the DEAD box helicases. Rogers, G.W., Komar, A.A., Merrick, W.C. Prog. Nucleic Acid Res. Mol. Biol. (2002) [Pubmed]
  4. Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. Rogers, G.W., Richter, N.J., Lima, W.F., Merrick, W.C. J. Biol. Chem. (2001) [Pubmed]
  5. Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H. Richter, N.J., Rogers, G.W., Hensold, J.O., Merrick, W.C. J. Biol. Chem. (1999) [Pubmed]
  6. Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H. Richter-Cook, N.J., Dever, T.E., Hensold, J.O., Merrick, W.C. J. Biol. Chem. (1998) [Pubmed]
  7. Integration of hepatitis B virus DNA into chromosomal DNA during acute hepatitis B. Kimbi, G.C., Kramvis, A., Kew, M.C. World J. Gastroenterol. (2005) [Pubmed]
  8. mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. Feng, P., Everly, D.N., Read, G.S. J. Virol. (2005) [Pubmed]
  9. mRNA decay during herpesvirus infections: interaction between a putative viral nuclease and a cellular translation factor. Feng, P., Everly, D.N., Read, G.S. J. Virol. (2001) [Pubmed]
  10. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. Osborne, L.R., Martindale, D., Scherer, S.W., Shi, X.M., Huizenga, J., Heng, H.H., Costa, T., Pober, B., Lew, L., Brinkman, J., Rommens, J., Koop, B., Tsui, L.C. Genomics (1996) [Pubmed]
  11. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale, D.W., Wilson, M.D., Wang, D., Burke, R.D., Chen, X., Duronio, V., Koop, B.F. Mamm. Genome (2000) [Pubmed]
  12. Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis. Tomonaga, T., Matsushita, K., Yamaguchi, S., Oh-Ishi, M., Kodera, Y., Maeda, T., Shimada, H., Ochiai, T., Nomura, F. Clin. Cancer Res. (2004) [Pubmed]
  13. De novo 46,XX,t(6;7)(q27;q11;23) associated with severe cardiovascular manifestations characteristic of supravalvular aortic stenosis and Williams syndrome. von Dadelszen, P., Chitayat, D., Winsor, E.J., Cohen, H., MacDonald, C., Taylor, G., Rose, T., Hornberger, L.K. Am. J. Med. Genet. (2000) [Pubmed]
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