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Gene Review

Eif4b  -  eukaryotic translation initiation factor 4B

Mus musculus

Synonyms: 2310046H11Rik, AL024095, C85189, Eif4a2, Eukaryotic translation initiation factor 4B, ...
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Disease relevance of Eif4b


High impact information on Eif4b

  • The translation initiation factor eIF4A is the prototypical DEAD-box RNA helicase that works in conjunction with eIF4B and eIF4H and as a subunit of eIF4F to prepare the mRNA template for ribosome binding, possibly by unwinding the secondary structure proximal to the 5' m7GpppN cap structure [2].
  • Furthermore, assembly of the eIF4F complex at the cap structure, as well as ATP hydrolysis, is shown to be a requisite for the cross-linking of another initiation factor, eIF4B, to the cap structure [3].
  • Phosphorylation of both the p25 and p220 subunits of eIF-4F is stimulated typically by 2.5-5-fold, with a 2-4-fold increase in phosphorylation of eIF-4B and eIF-3 p120 [4].
  • Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters [4].
  • The inhibition of translation is associated with specific cleavages of polypeptide chain initiation factors eIF4GI and eIF4B, a phenomenon previously observed in cells induced to undergo apoptosis in response to other stimuli [5].

Anatomical context of Eif4b

  • In this study, stimulation of phosphate labelling of S6, eIF-4F and eIF-4B in response to insulin and PMA has been examined in 3T3-L1 cells and compared with changes in protein synthesis [6].
  • This activity of the ribosomal wash from serum-deprived cells can be restored to control level with rabbit reticulocyte initiation factor eIF-4B only [7].


  1. Initiation of protein synthesis in neuroblastoma cells infected by Semliki Forest Virus. A decreased requirement of late viral mRNA for eIF-4B and cap binding protein. van Steeg, H., van Grinsven, M., van Mansfeld, F., Voorma, H.O., Benne, R. FEBS Lett. (1981) [Pubmed]
  2. Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Bordeleau, M.E., Matthews, J., Wojnar, J.M., Lindqvist, L., Novac, O., Jankowsky, E., Sonenberg, N., Northcote, P., Teesdale-Spittle, P., Pelletier, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure. Haghighat, A., Sonenberg, N. J. Biol. Chem. (1997) [Pubmed]
  4. Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters. Morley, S.J., Traugh, J.A. J. Biol. Chem. (1990) [Pubmed]
  5. p53-induced inhibition of protein synthesis is independent of apoptosis. Constantinou, C., Bushell, M., Jeffrey, I.W., Tilleray, V., West, M., Frost, V., Hensold, J., Clemens, M.J. Eur. J. Biochem. (2003) [Pubmed]
  6. Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6. Morley, S.J., Traugh, J.A. Biochimie (1993) [Pubmed]
  7. The effect of serum deprivation on the initiation of protein synthesis in mouse neuroblastoma cells. Salimans, M.M., van Heugten, H.A., van Steeg, H., Voorma, H.O. Biochim. Biophys. Acta (1985) [Pubmed]
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