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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AAK1  -  AP2 associated kinase 1

Homo sapiens

Synonyms: AP2-associated protein kinase 1, Adaptor-associated kinase 1, DKFZp686K16132, KIAA1048
 
 
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High impact information on AAK1

  • WT AAK1 overexpression selectively blocks transferrin (Tfn) receptor and LRP endocytosis [1].
  • Here, we examined the effects of adenoviral-mediated overexpression of WT AAK1, kinase-dead, and truncation mutants in HeLa cells, and show that AAK1 also regulates AP-2 function in vivo [1].
  • Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis [2].
  • In neuronal cells, AAK1 is enriched at presynaptic terminals, whereas in nonneuronal cells it colocalizes with clathrin and AP2 in clathrin-coated pits and at the leading edge of migrating cells [2].
  • We also found that HEK293 cells that overexpressed AAK1, a member of the human Ark/Prk family, were Adriamycin resistant [3].
 

Associations of AAK1 with chemical compounds

  • In vitro kinase assays reveal little difference between AAK1 isoforms in their basal or clathrin-stimulated kinase activity toward the AP-2 micro2 subunit [4].

References

  1. Differential requirements for AP-2 in clathrin-mediated endocytosis. Conner, S.D., Schmid, S.L. J. Cell Biol. (2003) [Pubmed]
  2. Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. Conner, S.D., Schmid, S.L. J. Cell Biol. (2002) [Pubmed]
  3. Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. Takahashi, T., Furuchi, T., Naganuma, A. Cancer Res. (2006) [Pubmed]
  4. A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. Henderson, D.M., Conner, S.D. Mol. Biol. Cell (2007) [Pubmed]
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