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SEPT8  -  septin 8

Homo sapiens

Synonyms: KIAA0202, SEP2, Septin-8
 
 
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High impact information on SEPT8

  • SEPT11 has strong homology to SEPT8 [1].
  • Thus, SEPT4 is the third described platelet septin besides SEPT5 and SEPT8 [2].
  • Using the yeast two-hybrid system with SEPT8 as bait protein we identified the human septin SEPT4 as an interaction partner of SEPT8 [2].
  • SEP3 and SEP2 measures demonstrated the significant superiority of vardenafil over placebo from week 2 onwards (p<0.001) [3].
  • Patients treated with vardenafil 8hours before sexual activity achieved clinically meaningful (>/=18%) and statistically significantly greater least-squares mean per-patient SEP3 and SEP2 success rates over weeks 2-10, compared with patients receiving placebo (SEP3 69% vs 34%; SEP2 81% vs 51%; both p<0.001) [3].
 

Associations of SEPT8 with chemical compounds

  • Successful SEP2 rates increased after vardenafil, reaching 84% at weeks 8 and 12 vs. 49-53% receiving placebo (p<0.005 vs. placebo) [4].
  • The time between sildenafil ingestion and intercourse attempt (0-0.5 to >10 hours) had no significant effect on responses to SEP2, but decreased responses to SEP3 from a maximum of 92.8% at 1.5-2 hours to 81.6% at more than 10 hours (P = 0.003) [5].
 

Other interactions of SEPT8

References

  1. Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5. Bläser, S., Röseler, S., Rempp, H., Bartsch, I., Bauer, H., Lieber, M., Lessmann, E., Weingarten, L., Busse, A., Huber, M., Zieger, B. J. Pathol. (2006) [Pubmed]
  2. The novel human platelet septin SEPT8 is an interaction partner of SEPT4. Bläser, S., Horn, J., Würmell, P., Bauer, H., Strümpell, S., Nurden, P., Pagenstecher, A., Busse, A., Wunderle, D., Hainmann, I., Zieger, B. Thromb. Haemost. (2004) [Pubmed]
  3. Extended duration of efficacy of vardenafil when taken 8 hours before intercourse: a randomized, double-blind, placebo-controlled study. Porst, H., Sharlip, I.D., Hatzichristou, D., Rubio-Aurioles, E., Gittelman, M., Stancil, B.N., Smith, P.M., Wilkins, H.J., Pommerville, P. Eur. Urol. (2006) [Pubmed]
  4. The efficacy and safety of flexible-dose vardenafil (levitra) in a broad population of European men. Hatzichristou, D., Montorsi, F., Buvat, J., Laferriere, N., Bandel, T.J., Porst, H. Eur. Urol. (2004) [Pubmed]
  5. Do food and dose timing affect the efficacy of sildenafil? A randomized placebo-controlled study. Zinner, N. The journal of sexual medicine (2007) [Pubmed]
  6. Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol. Martínez, C., Sanjuan, M.A., Dent, J.A., Karlsson, L., Ware, J. Biochem. J. (2004) [Pubmed]
  7. KIAA0202, a human septin family member, interacting with hPFTAIRE1. Yang, T., Gao, Y.K., Chen, J.Y. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2002) [Pubmed]
  8. Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. Sui, L., Zhang, W., Liu, Q., Chen, T., Li, N., Wan, T., Yu, M., Cao, X. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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