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Gene Review

SEPT4  -  septin 4

Homo sapiens

Synonyms: ARTS, Apoptosis-related protein in the TGF-beta signaling pathway, BRADEION, Bradeion beta, Brain protein H5, ...
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Disease relevance of SEPT4

  • These data raise the possibility that Sept4 is involved in the formation of cytoplasmic inclusions as well as induction of cell death in alpha-synuclein-associated neurodegenerative disorders [1].
  • In previous studies, it has been reported that both S. enteritidis, the most common serotype, and S. enteritidis Phage Type 4 (SEPT 4) isolates were identified as the most prevalent PT in domestic poultry and also in humans in Korea until 2002 [2].
  • Thirty-six SEPT 4 isolates were analyzed and differentiated with 10 pulsed-field profiles (PFP) expressing very high discriminative ability (SID: 0.921) [2].

Psychiatry related information on SEPT4

  • The Libri morales in the Faculty of Arts and Medicine at Bologna: Bartolomeo da Varignana and the Pseudo-Aristotelian Economics [3].

High impact information on SEPT4

  • The Genomation Laboratory, with corporate partners Orca Photonic Systems, Inc. and Engineering Arts, has developed modules for aspiration, dispensing, mixing, transport, and rapid thermal processing of biological samples contained in glass capillaries [4].
  • When co-expressed in cultured cells, FLAG-tagged Sept4 and Myc-tagged alpha-synuclein formed detergent-insoluble complex, and upon treatment with a proteasome inhibitor, they formed Lewy body-like cytoplasmic inclusions [1].
  • The first potential hairpin is located directly after the termination codon of the H5 gene and is highly conserved, whereas the second stem and loop structure maps shortly upstream of the polyadenylation site and shows a homology block at the central part of this inverted DNA repeat [5].
  • Thus, SEPT4 is the third described platelet septin besides SEPT5 and SEPT8 [6].
  • The novel human platelet septin SEPT8 is an interaction partner of SEPT4 [6].

Biological context of SEPT4

  • We assigned two human expressed sequence tags (ESTs), WI-15444 and SGC32067, homologous to mouse brain protein h5, to the critical region for Meckel syndrome (MKS) on 17q22-q23 [7].
  • Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene [7].
  • Paris, at the centre of the French scientific and medical environment, had only a few medical artists, the situation was therefore propitious to the creation of the College. How could a freelance medical artist establish a medical illustration college in a National Arts School [8]?
  • Harp lessons. Healing Arts Radiation Protection Act [9].
  • The aim of this study was to analyze the genetic diversity and epidemiological properties of both PT isolates, and also to trace the source of SEPT 4 isolates from domestic poultry and humans by Pulsed-field gel electrophoresis (PFGE) [2].

Anatomical context of SEPT4

  • SEPT8-IR almost paralleled that of SEPT4, except for a lower SEPT8-IR of the outer photoreceptor segments and a positive staining of the meningothelial cell nests in the subarachnoidal space of the bulbar segment of the orbital optic nerve [10].
  • In mouse and human spermatozoa, SEPT4 and other septins are found in the annulus, a cortical ring which separates the middle and principal pieces [11].
  • In Northern analysis, PNUTL2 is ubiquitously expressed as a 1.7-kb transcript in adult and fetal tissues with particularly high expression in the heart, liver, and adrenal gland [7].
  • We compare the exon/intron structure of both genes, the steady-state mRNA levels in tumor cell lines and adult organs, the conceptual translation products from alternatively processed mRNAs and the development of specific immunologic reagents distinguishing either PNUTL1 or PNUTL2 [12].
  • In contrast, H5 associates with the entire length of the stress fibers and the cortical actin network [13].

Associations of SEPT4 with chemical compounds


Other interactions of SEPT4


Analytical, diagnostic and therapeutic context of SEPT4

  • Mutation analysis using sequencing of RT-PCR products and Northern blot analysis in MKS patients exclude PNUTL2 as the gene for MKS [7].
  • In order to understand the molecular epidemiologic properties of SEPT 4 isolates, which have very similar phenotypic properties to our preliminary investigations (serotyping, phage typing, large plasmids and antibiograms), PFGE analysis with XbaI enzyme was performed on the representative SEPT 4 isolates [2].


  1. Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies. Ihara, M., Tomimoto, H., Kitayama, H., Morioka, Y., Akiguchi, I., Shibasaki, H., Noda, M., Kinoshita, M. J. Biol. Chem. (2003) [Pubmed]
  2. Finding the sources of Korean Salmonella enterica serovar Enteritidis PT 4 isolates by pulsed-field gel electrophoresis. Woo, Y.K. J. Microbiol. (2005) [Pubmed]
  3. The Libri morales in the Faculty of Arts and Medicine at Bologna: Bartolomeo da Varignana and the Pseudo-Aristotelian Economics. Siraisi, N.G. Manuscripta. (1976) [Pubmed]
  4. ACAPELLA-1K, a capillary-based submicroliter automated fluid handling system for genome analysis. Meldrum, D.R., Evensen, H.T., Pence, W.H., Moody, S.E., Cunningham, D.L., Wiktor, P.J. Genome Res. (2000) [Pubmed]
  5. Conserved dyad symmetry structures at the 3' end of H5 histone genes. Analysis of the duck H5 gene. Doenecke, D., Tönjes, R. J. Mol. Biol. (1984) [Pubmed]
  6. The novel human platelet septin SEPT8 is an interaction partner of SEPT4. Bläser, S., Horn, J., Würmell, P., Bauer, H., Strümpell, S., Nurden, P., Pagenstecher, A., Busse, A., Wunderle, D., Hainmann, I., Zieger, B. Thromb. Haemost. (2004) [Pubmed]
  7. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Paavola, P., Horelli-Kuitunen, N., Palotie, A., Peltonen, L. Genomics (1999) [Pubmed]
  8. The first college of medical illustration in Paris (France)--two years' experience. Barnaud, A. The Journal of audiovisual media in medicine. (1994) [Pubmed]
  9. Harp lessons. Healing Arts Radiation Protection Act. Barlow, W.R. Ontario dentist. (1995) [Pubmed]
  10. Immunoreactivity of the septins SEPT4, SEPT5, and SEPT8 in the human eye. Pache, M., Zieger, B., Bläser, S., Meyer, P. J. Histochem. Cytochem. (2005) [Pubmed]
  11. Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Ihara, M., Kinoshita, A., Yamada, S., Tanaka, H., Tanigaki, A., Kitano, A., Goto, M., Okubo, K., Nishiyama, H., Ogawa, O., Takahashi, C., Itohara, S., Nishimune, Y., Noda, M., Kinoshita, M. Dev. Cell (2005) [Pubmed]
  12. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. Zieger, B., Tran, H., Hainmann, I., Wunderle, D., Zgaga-Griesz, A., Blaser, S., Ware, J. Gene (2000) [Pubmed]
  13. Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins. Xie, H., Surka, M., Howard, J., Trimble, W.S. Cell Motil. Cytoskeleton (1999) [Pubmed]
  14. SEPT5_v2 is a parkin-binding protein. Choi, P., Snyder, H., Petrucelli, L., Theisler, C., Chong, M., Zhang, Y., Lim, K., Chung, K.K., Kehoe, K., D'Adamio, L., Lee, J.M., Cochran, E., Bowser, R., Dawson, T.M., Wolozin, B. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  15. ASPO Distinguished Achievement Award Lecture. Studies on the epidemiology and natural history of benign breast disease and breast cancer using nipple aspirate fluid. Petrakis, N.L. Cancer Epidemiol. Biomarkers Prev. (1993) [Pubmed]
  16. The Tai Sophia Institute for the Healing Arts. Horrigan, B. Explore (New York, N.Y.) (2006) [Pubmed]
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