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Gene Review:

Txnrd3 - thioredoxin reductase 3

Mus musculus

Synonyms: AI196535, TR2, Tgr, Thioredoxin and glutathione reductase, Thioredoxin reductase 3, ...

Moustafa, M.E. et al., Eckenroth, B. et al.

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Disease relevance of Txnrd3

This method produces the first 487 amino acids of mouse thioredoxin reductase-3 as an intein fusion protein in Escherichia coli cells [1].

High impact information on Txnrd3

Cytosolic glutathione peroxidase and mitochondrial thioredoxin reductase 3 were the most and least affected selenoproteins, while selenoprotein expression was most and least affected in the liver and testes, respectively [2].

References

Semisynthesis and characterization of mammalian thioredoxin reductase. Eckenroth, B., Harris, K., Turanov, A.A., Gladyshev, V.N., Raines, R.T., Hondal, R.J. Biochemistry (2006) [Pubmed]
Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA. Moustafa, M.E., Carlson, B.A., El-Saadani, M.A., Kryukov, G.V., Sun, Q.A., Harney, J.W., Hill, K.E., Combs, G.F., Feigenbaum, L., Mansur, D.B., Burk, R.F., Berry, M.J., Diamond, A.M., Lee, B.J., Gladyshev, V.N., Hatfield, D.L. Mol. Cell. Biol. (2001) [Pubmed]

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