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Gene Review: 

Scgb2b24  -  secretoglobin, family 2B, member 24

Mus musculus

Synonyms: Abpbg24, Abpz, Allergen dI chain C2B, Androgen-binding protein zeta, C2b, ...
 
 
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High impact information on Abpz

  • The C2b portion of the C2 molecule may be important in assembly of the classical pathway C3-convertase [1].
  • Although the human AC9 sequence shows 86% homology with mouse AC9, divergence at the C2a/C2b junction results in an alternative C2b amino acid sequence [2].
  • Co2+ enhances C2b and C3 formation and inhibits C4 formation [3].

References

  1. Evidence for a C4b binding site on the C2b domain of C2. Oglesby, T.J., Accavitti, M.A., Volanakis, J.E. J. Immunol. (1988) [Pubmed]
  2. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). Hacker, B.M., Tomlinson, J.E., Wayman, G.A., Sultana, R., Chan, G., Villacres, E., Disteche, C., Storm, D.R. Genomics (1998) [Pubmed]
  3. Effects of metals on the binding of protein factors to the mouse 2',5'-oligoadenylate synthetase ME-12 gene regulatory region. Yan, C., Tamm, I. J. Interferon Res. (1991) [Pubmed]
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