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Scgb2b27  -  secretoglobin, family 2B, member 27

Mus musculus

Synonyms: Abpb, Abpbg27, Abpbg5, C2a, EG545947, ...
 
 
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High impact information on Abpb

  • The mycobacteria-associated C2a cleaved C3, resulting in C3b opsonization of the mycobacteria and recognition by macrophages [1].
  • This is consistent with the elevated evolutionary rates observed for the Abpa gene, and the Abpb and Abpg genes whose products (ABPbeta and ABPgamma) form heterodimers with ABPalpha [2].
  • C5 convertase of the classical complement pathway is a protein complex consisting of C4b, C2a, and C3b [3].
  • Although the human AC9 sequence shows 86% homology with mouse AC9, divergence at the C2a/C2b junction results in an alternative C2b amino acid sequence [4].
  • We compare the location of these genes with other secretoglobin genes in the mouse genome and with the known locations of secretoglobin genes in the human genome and present evidence that strong positive selection has driven the divergence of the coding regions of Abpb and Abpg since the putative duplication event that created them [5].
 

Associations of Abpb with chemical compounds

  • This pathway required the association of the complement cleavage product C2a with mycobacteria resulting in the formation of a C3 convertase [1].

References

  1. A macrophage invasion mechanism of pathogenic mycobacteria. Schorey, J.S., Carroll, M.C., Brown, E.J. Science (1997) [Pubmed]
  2. Comparative evolutionary genomics of androgen-binding protein genes. Emes, R.D., Riley, M.C., Laukaitis, C.M., Goodstadt, L., Karn, R.C., Ponting, C.P. Genome Res. (2004) [Pubmed]
  3. Covalent binding of C3b to C4b within the classical complement pathway C5 convertase. Determination of amino acid residues involved in ester linkage formation. Kim, Y.U., Carroll, M.C., Isenman, D.E., Nonaka, M., Pramoonjago, P., Takeda, J., Inoue, K., Kinoshita, T. J. Biol. Chem. (1992) [Pubmed]
  4. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). Hacker, B.M., Tomlinson, J.E., Wayman, G.A., Sultana, R., Chan, G., Villacres, E., Disteche, C., Storm, D.R. Genomics (1998) [Pubmed]
  5. The mouse salivary androgen-binding protein (ABP) gene cluster on Chromosomes 7: characterization and evolutionary relationships. Laukaitis, C.M., Dlouhy, S.R., Karn, R.C. Mamm. Genome (2003) [Pubmed]
 
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