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Gene Review

Scgb2b26  -  secretoglobin, family 2B, member 26

Mus musculus

Synonyms: Abpbg26, Abpbg4, Abpg, C2d, Scgb2b4
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High impact information on Abpg

  • To further examine the role of MHC II and CD4 T cells, we irradiated C2d mice and reconstituted them with C57BL/6 bone marrow alone or with C57BL/6 CD4 T cells [1].
  • We infected C57BL/6, athymic, CD4-deficient, CD8alpha-deficient, and major histocompatibility complex class II (MHC II)-deficient (C2d) mice with Trichinella spiralis larvae [1].
  • Athymic and C2d mice exhibited much smaller increases in muscle contraction and delayed parasite expulsion [1].
  • Following oral immunization with cholera toxin, C57BL/6 mice responded with IgA and IgG antibody, and had increased numbers of IgA plasma cells, but C2d mice gave no response [2].
  • The Peyer's patch and mesenteric lymph node tissues of C2d mice contained very few CD4-expressing T cells [2].

Biological context of Abpg

  • We compare the location of these genes with other secretoglobin genes in the mouse genome and with the known locations of secretoglobin genes in the human genome and present evidence that strong positive selection has driven the divergence of the coding regions of Abpb and Abpg since the putative duplication event that created them [3].
  • We investigated IgA production by C2d mice and their IgA antibody response to antigen given orally [2].

Anatomical context of Abpg

  • C57BL/6 bone marrow alone did not affect muscle function or worm expulsion in recipient C2d mice [1].


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