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Gene Review

SLC9A8  -  solute carrier family 9, subfamily A (NHE8...

Homo sapiens

Synonyms: KIAA0939, NHE-8, NHE8, Na(+)/H(+) exchanger 8, Sodium/hydrogen exchanger 8, ...
 
 
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High impact information on SLC9A8

  • The major subgroups are plasma membrane (recycling and resident) and intracellular (endosomal/TGN, NHE8-like, and plant vacuolar) [1].
  • NHE8 is a newly identified isoform also expressed on the brush border in the proximal tubule, but its function remains unknown [2].

References

  1. Evolutionary origins of eukaryotic sodium/proton exchangers. Brett, C.L., Donowitz, M., Rao, R. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  2. Ion exchangers mediating Na+, HCO3 - and Cl- transport in the renal proximal tubule. Aronson, P.S. J. Nephrol. (2006) [Pubmed]
 
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