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Disease relevance of Microvilli


Psychiatry related information on Microvilli


High impact information on Microvilli

  • AQP7 is abundant in the brush border of proximal tubule cells and is likely to be involved in proximal tubule water reabsorption [7].
  • Among the molecularly identified sodium-phosphate (Na/P(i)) cotransport systems a brush-border membrane type IIa Na-P(i) cotransporter is the key player in proximal tubular P(i) reabsorption [8].
  • HCP 1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency [9].
  • Upon LKB1 activation, single cells rapidly remodel their actin cytoskeleton to form an apical brush border [10].
  • The junctional proteins ZO-1 and p120 redistribute in a dotted circle peripheral to the brush border, in the absence of cell-cell contacts [10].

Chemical compound and disease context of Microvilli


Biological context of Microvilli


Anatomical context of Microvilli


Associations of Microvilli with chemical compounds


Gene context of Microvilli

  • The enhanced function of LECAM-1-associated sLex may reflect the striking concentration, shown here, of LECAM-1 on PMN surface microvilli, the site of initial cellular contact [29].
  • Moreover, EBP50 and ezrin can be coimmunoprecipitated as a complex from isolated human placental microvilli [30].
  • The ezrin/radixin/moesin antisense PONs mixture induced the destruction of both cell-cell and cell-substrate adhesion, as well as the disappearance of microvilli [31].
  • Addition of ezrin antisense oligonucleotides to primary cultures of rat RPE drastically decreased both apical microvilli and basal infoldings [32].
  • Cad99C specifically localizes to apical microvilli [33].

Analytical, diagnostic and therapeutic context of Microvilli


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  17. Villin induces microvilli growth and actin redistribution in transfected fibroblasts. Friederich, E., Huet, C., Arpin, M., Louvard, D. Cell (1989) [Pubmed]
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  20. An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin. Friederich, E., Vancompernolle, K., Huet, C., Goethals, M., Finidori, J., Vandekerckhove, J., Louvard, D. Cell (1992) [Pubmed]
  21. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., Butcher, E.C. Cell (1995) [Pubmed]
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  30. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. Reczek, D., Berryman, M., Bretscher, A. J. Cell Biol. (1997) [Pubmed]
  31. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S., Tsukita, S. J. Cell Biol. (1994) [Pubmed]
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