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FNTA  -  farnesyltransferase, CAAX box, alpha

Homo sapiens

Synonyms: CAAX farnesyltransferase subunit alpha, FPTA, FTase-alpha, GGTase-I-alpha, PGGT1A, ...
 
 
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High impact information on FNTA

  • cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences [1].
  • Insulin-stimulated VSMC expressing the FTase alpha-subunit (S60A,S62A) showed decreased (i) phosphorylation of FTase, (ii) FTase activity, (iii) amounts of farnesylated p21Ras, (iv) DNA synthesis, and (v) migration [2].

References

  1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. Andres, D.A., Milatovich, A., Ozçelik, T., Wenzlau, J.M., Brown, M.S., Goldstein, J.L., Francke, U. Genomics (1993) [Pubmed]
  2. Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects. Solomon, C.S., Goalstone, M.L. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
 
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