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Fnta  -  farnesyltransferase, CAAX box, alpha

Mus musculus

Synonyms: CAAX farnesyltransferase subunit alpha, FTA, FTase-alpha, GGTase-I-alpha, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ...
 
 
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High impact information on Fnta

  • In contrast, 3T3-L1 fibroblasts, expressing the constitutively active Raf-1, exhibited enhanced phosphorylation of the FTase alpha-subunit [1].
  • Furthermore, expression of the dominant negative mutant of p21Ras precluded insulin-stimulated phosphorylation of the FTase alpha-subunit and activation of its enzymatic activity [1].
  • Insulin increased the amounts of FTase alpha- and beta-subunit mRNA in 3T3-L1 fibroblasts 2.5-fold to 4-fold after 6 h and 24 h incubation, respectively, but did not increase the rate of FTase transcription over a 24 h period [2].

References

  1. Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway. Goalstone, M., Carel, K., Leitner, J.W., Draznin, B. Endocrinology (1997) [Pubmed]
  2. Effect of insulin on farnesyltransferase gene transcription and mRNA stability. Goalstone, M.L., Draznin, B. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
 
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